Journal of Korean Academy of Nursing

Effect of Regular Exercise during Recovery Period Following Steroid Treatment on the Atrophied Type II Muscles Induced by Steroid in Young Rats: Myoung Ae Choe, Gi Soo Shin, Gyeong Ju An, Jung An Choi, Yoon Kyong Lee; Journal of Korean Academy of Nursing 2002;32(4):550-559. Published online March 29, 2017; DOI: https://doi.org/10.4040/jkan.2002.32.4.550

PURPOSE: This study was conducted to determine whether low intensity regular exercise following dexamethasone treatment could attenuate steroid-induced muscle atrophy. METHOD: 36 Wistar-rats(90-110g) were divided into six groups: control group(C), dexamethasone treatment group(D), sedentary group after normal sedentary period(C+S), sedentary group after dexamethasone treatment period(D+S), exercise group after normal sedentary period(C+E), and excercise group after dexamethasone treatment period(D+E). D, D+S, and D+E groups received dexamethasone injection(5mg/Kg) for seven days whereas C, C+S, and C+E groups received normal saline injection. Both C+E and D+E groups ran on a treadmill for 60 minutes/day(20minutes/4hours) at 15m/min and a 10degreegrade for seven recovery days. RESULT: Post-weight(body weight before muscle dissection) of D group significantly decreased by 16.03%, and that of D+E group significantly increased by 15.51% compared with pre-weight(body weight before steroid treatment). Type II muscle(plantaris and gastrocnemius) weights of D group were significantly lower than those of C group. Myofibrillar protein contents of type II muscles of D group tended to decrease comparing with C group. In D+E groups, body weights and relative weights of typeII muscles(muscle weight(mg)/post-weight(g)) tended to increase comparing with D+S group. CONCLUSION: It is suggested that steroid- induced muscle atrophy can be ameliorated through low intensity regular exercise after dexamethasone treatment.

Citations

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Use of Animals for Nursing Research in Korea
Hae Young Yoo
Journal of Korean Biological Nursing Science.2015; 17(4): 324. CrossRef
Effect of DHEA Administration Alone or Exercise combined with DHEA before Steroid Treatment on Rat Hindlimb Muscles
Myoung-Ae Choe, Gyeong-Ju An
Journal of Korean Academy of Nursing.2009; 39(3): 321. CrossRef

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Effects of Exercise on Affected and Unaffected Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury: Myoung-Ae Choe, Gyeong Ju An; J Korean Acad Nurs 2010;40(5):611-619. Published online October 31, 2010; DOI: https://doi.org/10.4040/jkan.2010.40.5.611

Abstract PDF

Purpose

The purpose of this study was to examine the effects of exercise on muscle weight and Type I and II fiber cross-sectional area of affected and unaffected hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury.

Methods

Neuropathic pain was induced by ligation and cutting of the left L5 spinal nerve. Adult male Sprague-Dawley rats were randomly assigned to one of two groups: The Pain+Exercise (PE) group (n=21) and the Sham+Exercise (SE) group (n=20). All rats had 28 sessions of treadmill exercise at grade 10 for 30 minutes, twice/day at 10 m/min for 14 days. Body weight, food intake and activity were measured every day. At 15 days all rats were anesthetized and soleus, plantaris and gastrocnemius muscles were dissected. Muscle weight and Type I, II fiber cross-sectional area of the dissected muscles were measured.

Results

The PE group showed significant increases (p<.05), as compared to the SE group for body weight and total diet intake, muscle weight of the unaffected soleus and plantaris, and in Type I and II fiber cross-sectional area of unaffected three muscles and affected plantaris.

Conclusion

Exercise for 14 days attenuates unaffected soleus, plantaris and gastrocnemius muscle atrophy in neuropathic pain model.

Citations

Citations to this article as recorded by

Use of Animals for Nursing Research in Korea
Hae Young Yoo
Journal of Korean Biological Nursing Science.2015; 17(4): 324. CrossRef
An Intensive Locomotor Training Paradigm Improves Neuropathic Pain following Spinal Cord Compression Injury in Rats
Elizabeth A. Dugan, Jacqueline Sagen
Journal of Neurotrauma.2015; 32(9): 622. CrossRef
Effects of Nitric Oxide Synthase Inhibitor on Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury
Myoung-Ae Choe, Gyeong Ju An
Journal of Korean Academy of Nursing.2011; 41(4): 520. CrossRef

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Effect of Dehydroepiandrosterone on Affected and Unaffected Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury: Myoung-Ae Choe, Gyeong Ju An; J Korean Acad Nurs 2009;39(5):632-640. Published online October 31, 2009; DOI: https://doi.org/10.4040/jkan.2009.39.5.632

Abstract PDF

Purpose

The purpose of this study was to examine the effect of DHEA (Dehydroepiandrosterone) on muscle weight and Type I and II fiber cross-sectional area of affected and unaffected hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury.

Methods

Neuropathic pain was induced by ligation and cutting of the left L5 spinal nerve. Adult male Sprague-Dawley rats were randomly assigned to one of two groups: The DHEA group (n=10) had DHEA injections daily for 14 days, and the Vehicle group (n=10) had vehicle injections daily for 14 days. Withdrawal threshold, body weight, food intake and activity were measured every day. At 15 days all rats were anesthetized and soleus, plantaris and gastrocnemius muscles were dissected from the both hindlimbs. Body weight, food intake, activity, muscle weight and Type I, II fiber cross-sectional area of the dissected muscles were measured.

Results

The DHEA group showed significant increases (p<.05), as compared to the vehicle group for muscle weight of the unaffected plantaris, and in Type II fiber cross-sectional area of the gastrocnemius muscle. The DHEA group demonstrated a higher pain threshold than the vehicle group whereas total diet intake and activity score were not significantly different between the two groups.

Conclusion

DHEA administration for 14 days attenuates unaffected plantaris and gastrocnemius muscle atrophy.

Citations

Citations to this article as recorded by

An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans
Jennifer C. Naylor, Jason D. Kilts, Jennifer L. Strauss, Steven T. Szabo, Charlotte E. Dunn, H. Ryan Wagner, Robert M. Hamer, Lawrence J. Shampine, Joseph R. Zanga, Christine E. Marx
Journal of Rehabilitation Research and Development.2016; 53(4): 499. CrossRef
Effects of Nitric Oxide Synthase Inhibitor on Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury
Myoung-Ae Choe, Gyeong Ju An
Journal of Korean Academy of Nursing.2011; 41(4): 520. CrossRef
Effects of Exercise on Affected and Unaffected Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury
Myoung-Ae Choe, Gyeong Ju An
Journal of Korean Academy of Nursing.2010; 40(5): 611. CrossRef

156 View
0 Download
3 Crossref

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