Myoung-Ae Choe; Gyeong Ju An

doi:10.4040/jkan.2010.40.5.611

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Original Article
Effects of Exercise on Affected and Unaffected Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury: Myoung-Ae Choe, Gyeong Ju An; Journal of Korean Academy of Nursing 2010;40(5):611-619.
DOI: https://doi.org/10.4040/jkan.2010.40.5.611
Published online: October 31, 2010

¹Professor, College of Nursing, Seoul National University, Seoul, Korea.

²Professor, Department of Nursing, Cheongju University, Cheongju, Korea.

Address reprint requests to: Choe, Myoung-Ae. College of Nursing, Seoul National University, 28 Yeongeon-dong, Jongno-gu, Seoul 110-744, Korea. Tel: 82-2-740-8824, Fax: 82-2-765-4103, machoe@snu.ac.kr

• Received: April 29, 2010 • Accepted: October 14, 2010

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Abstract
NOTES
REFERENCES

Abstract

Purpose
The purpose of this study was to examine the effects of exercise on muscle weight and Type I and II fiber cross-sectional area of affected and unaffected hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury.
Methods
Neuropathic pain was induced by ligation and cutting of the left L5 spinal nerve. Adult male Sprague-Dawley rats were randomly assigned to one of two groups: The Pain+Exercise (PE) group (n=21) and the Sham+Exercise (SE) group (n=20). All rats had 28 sessions of treadmill exercise at grade 10 for 30 minutes, twice/day at 10 m/min for 14 days. Body weight, food intake and activity were measured every day. At 15 days all rats were anesthetized and soleus, plantaris and gastrocnemius muscles were dissected. Muscle weight and Type I, II fiber cross-sectional area of the dissected muscles were measured.
Results
The PE group showed significant increases (p<.05), as compared to the SE group for body weight and total diet intake, muscle weight of the unaffected soleus and plantaris, and in Type I and II fiber cross-sectional area of unaffected three muscles and affected plantaris.
Conclusion
Exercise for 14 days attenuates unaffected soleus, plantaris and gastrocnemius muscle atrophy in neuropathic pain model.
Keywords: Pain; Exercise; Muscular atrophy; Muscle weight; Muscle fiber

This work was supported by Mid-career Researcher Program through NRF grant funded by the MEST (2009-0053460).

REFERENCES

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Figure 1

Cross-section of the hindlimb muscles in Pain+Exercise and Sham+Exercise rats. The first line is the affected soleus (left), plantaris (middle) and gastrocnemius muscle (right) in Pain+Exercise rats. The second line is the unaffected soleus (left), plantaris (middle) and gastrocnemius muscle (right) in Pain+Exercise rats. The third line is the affected soleus (left), plantaris (middle) and gastrocnemius muscle (right) in Sham+Exercise rats. The fourth line is the unaffected soleus (left), plantaris (middle) and gastrocnemius muscle (right) in Sham+Exercise rats. Dark=Type I muscle fiber, light=Type II muscle fiber (Myosin ATPase straining, 100×).

Table 1

Body Weight and Total Diet Intake of Pain+Exercise and Sham+Exercise Rats

Table 2

Total Activity Score of Pain+Exercise and Sham+Exercise Rats

Table 3

Muscle Weight of Pain+Exercise and Sham+Exercise Rats

Table 4

Cross-Sectional Area of the Hindlimb Muscles in Pain+Exercise and Sham+Exercise Rats

Figure & Data

REFERENCES

Citations

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Effects of Exercise on Affected and Unaffected Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury

J Korean Acad Nurs. 2010;40(5):611-619. Published online October 31, 2010

DOI: https://doi.org/10.4040/jkan.2010.40.5.611

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Effects of Exercise on Affected and Unaffected Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury

Figure 1 Cross-section of the hindlimb muscles in Pain+Exercise and Sham+Exercise rats. The first line is the affected soleus (left), plantaris (middle) and gastrocnemius muscle (right) in Pain+Exercise rats. The second line is the unaffected soleus (left), plantaris (middle) and gastrocnemius muscle (right) in Pain+Exercise rats. The third line is the affected soleus (left), plantaris (middle) and gastrocnemius muscle (right) in Sham+Exercise rats. The fourth line is the unaffected soleus (left), plantaris (middle) and gastrocnemius muscle (right) in Sham+Exercise rats. Dark=Type I muscle fiber, light=Type II muscle fiber (Myosin ATPase straining, 100×).

Figure 1

Effects of Exercise on Affected and Unaffected Hindlimb Muscles in Rats with Neuropathic Pain Induced by Unilateral Peripheral Nerve Injury

Table 1

Body Weight and Total Diet Intake of Pain+Exercise and Sham+Exercise Rats

Table 2

Total Activity Score of Pain+Exercise and Sham+Exercise Rats

Table 3

Muscle Weight of Pain+Exercise and Sham+Exercise Rats

Table 4

Cross-Sectional Area of the Hindlimb Muscles in Pain+Exercise and Sham+Exercise Rats

Table 1 Body Weight and Total Diet Intake of Pain+Exercise and Sham+Exercise Rats

Table 2 Total Activity Score of Pain+Exercise and Sham+Exercise Rats

Table 3 Muscle Weight of Pain+Exercise and Sham+Exercise Rats

Table 4 Cross-Sectional Area of the Hindlimb Muscles in Pain+Exercise and Sham+Exercise Rats