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Original Article
Structural Equation Modeling on Quality of Life in Pre-dialysis Patients with Chronic Kidney Disease
Hye Won Kim1, Smi Choi-Kwon2
Journal of Korean Academy of Nursing 2012;42(5):699-708.
DOI: https://doi.org/10.4040/jkan.2012.42.5.699
Published online: October 12, 2012

1Department of Nursing, Konyang University, Daejeon, Korea

2College of Nursing, Seoul National University·Research Institute of Nursing Science, Seoul, Korea

1Department of Nursing, Konyang University, Daejeon, Korea

2College of Nursing, Seoul National University·Research Institute of Nursing Science, Seoul, Korea

Address reprint requests to : Choi-Kwon, Smi College of Nursing, Seoul National University 28 Yeongeon-dong, Chongro-gu Seoul 110-799 Korea Tel: +82-2-740-8830 Fax: +82-2-765-4103 E-mail: smi@snu.ac.kr
• Received: January 10, 2012   • Revised: February 14, 2012   • Accepted: September 24, 2012

Copyright © 2012 Korean Society of Nursing Science

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Purpose
    This study was designed to test structural equation modeling of the quality of life of pre-dialysis patients, in order to provide guidelines for the development of interventions and strategies to improve the quality of life of patients with Chronic Kidney Disease (CKD).
  • Methods
    Participants were patients who visited the nephrology outpatient department of a tertiary hospital located in Seoul. Data on demographic factors, social support, nutritional status, physical factors and biobehavioral factors and quality of life were collected between March 4 and March 31, 2011.
  • Results
    In the final analysis 208 patients were included. Of the patients 42% were in a malnourished state. Anxious or depressed patients accounted for 62.0%, 72.6%, respectively. Model fit indices for the hypothetical model were in good agreement with the recommended levels (GFI= .94 and CFI= .99). Quality of life in pre-dialysis patients with CKD was significantly affected by demographic factors, social support, nutritional status, physical factors and biobehavioral factors. Biobehavioral factors had the strongest and most direct influence on quality of life of patients with CKD.
  • Conclusion
    In order to improve the quality of life in pre-dialysis patients with CKD, comprehensive interventions are necessary to assess and manage biobehavioral factors, physical factors and nutritional status.
Figure 1.
Research framework.
jkan-42-699f1.jpg
Figure 2.
Path diagram for the hypothetical model.
jkan-42-699f2.jpg
Table 1.
General Characteristics of Participants (N=208)
Characteristics Categories n (%) or M±SD
Gender Male 125 (60.1)
Female 83 (39.9)
Age (year) 60.9±15.4
≤64 106 (51.0)
65-74 62 (29.8)
≥75 40 (19.2)
Educational level Elementary school 37 (17.7)
Middle school 32 (15.4)
High school 69 (33.2)
≥College 70 (33.7)
Occupation Yes 81 (38.9)
No 127 (61.1)
Monthly expenditure <100 56 (26.9)
   (10,000 won) 100-199 136 (65.4)
≥200 16 (7.7)
Table 2.
Descriptive Statistics of Observed Variables (N=208)
Variables Categories n (%) or M±SD Range
Social support 43.0±8.8 17.0-60.0
Nutritional status Severely malnourished 48 (23.1)
Moderately malnourished 40 (19.2)
Well nourished 120 (57.7)
Glomerular filtration rate 21.6±14.0 3-59
30-59 mL/min/1.73 m2 59 (28.4)
15-29 mL/min/1.73 m2 62 (29.8)
<15 mL/min/1.73 m2 87 (41.8)
Karnofsky performance scale 78.6±9.7 50-100
100-80 146 (70.2)
79-60 57 (27.4)
<60 5 (2.4)
Uremic symptoms 3.6±2.3 0-11.0
None 15 (7.2)
1-3 113 (54.3)
4-6 50 (24.0)
≥7 30 (14.5)
Comorbidities 1.5±0.9 0-4.0
None 21 (10.1)
1-2 154 (74.0)
≥3 33 (15.9)
Anemia Yes 162 (77.9)
No 46 (22.1)
Anxiety 12.5±4.2 7.0-26.0
No 18 (8.7)
Borderline 61 (29.3)
Yes 129 (62.0)
Depression 14.0±4.6 7.0-25.0
No 4 (1.9)
Borderline 53 (25.5)
Yes 151 (72.6)
Fatigue 38.3±16.3 9.0-63.0
Sleep disorder No 101 (48.6)
Yes 107 (51.4)
Sleep quality 48.3±14.8 12.0-79.0
Quality of life 51.5±20.3 6.7-97.2
Table 3.
Standardized Direct, Indirect and Total Effects for the Hypothetical Model
Endogenous variables Exogenous variables Standardized direct effect Standardized indirect effect Standardized total effect SMC
Quality of life Demographic factors −.23* −.30 −.53 .537
Social support .15* .15 .30
Nutritional status .31** −.47 −.16
Physical factors .34** .17 .51
Biobehavioral factors .40** .40
Nutritional status Demographic factors .34** .34 .211
Social support .31** .31
Physical factors Demographic factors −.42** −.16 −.58 .527
Social support .27** −.15 .12
Nutritional status −.47** −.47
Biobehavioral factors Demographic factors −.07 −.43 −.50 .807
Social support .15** −.13 .02
Nutritional status −.58** −.19 −.77
Physical factors .41** .41

SMC=Squared multiple correlations.

*p<.05; **p<.01.

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        Structural Equation Modeling on Quality of Life in Pre-dialysis Patients with Chronic Kidney Disease
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      Structural Equation Modeling on Quality of Life in Pre-dialysis Patients with Chronic Kidney Disease
      Image Image
      Figure 1. Research framework.
      Figure 2. Path diagram for the hypothetical model.
      Structural Equation Modeling on Quality of Life in Pre-dialysis Patients with Chronic Kidney Disease
      Characteristics Categories n (%) or M±SD
      Gender Male 125 (60.1)
      Female 83 (39.9)
      Age (year) 60.9±15.4
      ≤64 106 (51.0)
      65-74 62 (29.8)
      ≥75 40 (19.2)
      Educational level Elementary school 37 (17.7)
      Middle school 32 (15.4)
      High school 69 (33.2)
      ≥College 70 (33.7)
      Occupation Yes 81 (38.9)
      No 127 (61.1)
      Monthly expenditure <100 56 (26.9)
         (10,000 won) 100-199 136 (65.4)
      ≥200 16 (7.7)
      Variables Categories n (%) or M±SD Range
      Social support 43.0±8.8 17.0-60.0
      Nutritional status Severely malnourished 48 (23.1)
      Moderately malnourished 40 (19.2)
      Well nourished 120 (57.7)
      Glomerular filtration rate 21.6±14.0 3-59
      30-59 mL/min/1.73 m2 59 (28.4)
      15-29 mL/min/1.73 m2 62 (29.8)
      <15 mL/min/1.73 m2 87 (41.8)
      Karnofsky performance scale 78.6±9.7 50-100
      100-80 146 (70.2)
      79-60 57 (27.4)
      <60 5 (2.4)
      Uremic symptoms 3.6±2.3 0-11.0
      None 15 (7.2)
      1-3 113 (54.3)
      4-6 50 (24.0)
      ≥7 30 (14.5)
      Comorbidities 1.5±0.9 0-4.0
      None 21 (10.1)
      1-2 154 (74.0)
      ≥3 33 (15.9)
      Anemia Yes 162 (77.9)
      No 46 (22.1)
      Anxiety 12.5±4.2 7.0-26.0
      No 18 (8.7)
      Borderline 61 (29.3)
      Yes 129 (62.0)
      Depression 14.0±4.6 7.0-25.0
      No 4 (1.9)
      Borderline 53 (25.5)
      Yes 151 (72.6)
      Fatigue 38.3±16.3 9.0-63.0
      Sleep disorder No 101 (48.6)
      Yes 107 (51.4)
      Sleep quality 48.3±14.8 12.0-79.0
      Quality of life 51.5±20.3 6.7-97.2
      Endogenous variables Exogenous variables Standardized direct effect Standardized indirect effect Standardized total effect SMC
      Quality of life Demographic factors −.23* −.30 −.53 .537
      Social support .15* .15 .30
      Nutritional status .31** −.47 −.16
      Physical factors .34** .17 .51
      Biobehavioral factors .40** .40
      Nutritional status Demographic factors .34** .34 .211
      Social support .31** .31
      Physical factors Demographic factors −.42** −.16 −.58 .527
      Social support .27** −.15 .12
      Nutritional status −.47** −.47
      Biobehavioral factors Demographic factors −.07 −.43 −.50 .807
      Social support .15** −.13 .02
      Nutritional status −.58** −.19 −.77
      Physical factors .41** .41
      Table 1. General Characteristics of Participants (N=208)

      Table 2. Descriptive Statistics of Observed Variables (N=208)

      Table 3. Standardized Direct, Indirect and Total Effects for the Hypothetical Model

      SMC=Squared multiple correlations.

      *p<.05; **p<.01.


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