Kyung Yeon Kim; Seung Hee Lee; Jeong Hye Kim; Pok Ja Oh

doi:10.4040/jkan.2015.45.5.661

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Original Article
Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress: Kyung Yeon Kim, Seung Hee Lee, Jeong Hye Kim, Pok Ja Oh; Journal of Korean Academy of Nursing 2015;45(5):661-670.
DOI: https://doi.org/10.4040/jkan.2015.45.5.661
Published online: October 30, 2015

¹Korea Institude of Radiological & Medical Science, Seoul, Korea.

²Department of Clinical Nursing, University of Ulsan, Seoul, Korea.

³Department of Nursing, Sahmyook University, Seoul, Korea.

Address reprint requests to: Oh, Pok-Ja. Department of Nursing, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 01795, Korea. Tel: +82-2-3399-1589, Fax: +82-2-3399-1594, ohpj@syu.ac.kr

• Received: February 11, 2015 • Revised: February 17, 2015 • Accepted: June 5, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution NoDerivs License. (http://creativecommons.org/licenses/by-nd/4.0/) If the original work is properly cited and retained without any modification or reproduction, it can be used and re-distributed in any format and medium.

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Abstract
REFERENCES

Abstract

Purpose
The purpose of this study was to examine the mediation of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life in order to provide a basis for planning nursing interventions to improve the quality of life in cancer patients.
Methods
A purposive sample of 130 patients treated with chemotherapy were recruited in the cross-sectional survey design. Data were collected using self-report questionnaires. The instruments were the Chemotherapy Induced Peripheral Neuropathy Assessment Tool (CIPNAT), Hospital Anxiety Depression Scale (HADS), and Functional Assessment of Cancer Therapy-General (FACT-G).
Results
The mean score for disturbance in ADL from chemotherapy induced peripheral neuropathy was 3.30. Overall quality of life was 2.48. The mean score was 1.04 for psychological distress. The prevalence was 35.4% for anxiety and 47.7% for depression. There were significant correlations among the three variables, disturbance in ADL from chemotherapy induced peripheral neuropathy, psychosocial distress, and quality of life. Psychosocial distress had a complete mediating effect (β= -.74, p <.001) in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life (Sobel test: Z= -6.11, p <.001).
Conclusion
Based on the findings of this study, nursing intervention programs focusing on disturbance of ADL management, and decrease of psychological distress are highly recommended to improve quality of life in cancer patients.
Keywords: Quality of life; Peripheral neuropathy; Neoplasm; Depression

REFERENCES

1. National Cancer Information Center. Cancer facts & figure 2014. Seoul: Ministry of Health & Welfare, National Cancer Center; 2014.
2. Tofthagen CS, McMillan SC, Kip KE. Development and psychometric evaluation of the chemotherapy-induced peripheral neuropathy assessment tool. Cancer Nurs. 2011;34(4):E10–E20. Article
3. Tofthagen C. Patient perceptions associated with chemotherapy-induced peripheral neuropathy. Clin J Oncol Nurs. 2010;14(3):E22–E28. Article PubMed
4. Argyriou AA, Bruna J, Marmiroli P, Cavaletti G. Chemotherapy-induced peripheral neurotoxicity (CIPN): An update. Crit Rev Oncol Hematol. 2012;82(1):51–77. Article PubMed
5. Kwak MK, Kim EJ, Lee ER, Kwon IG, Hwang MS. Characteristics and quality of life in patients with chemotherapy-induced peripheral neuropathy. J Korean Oncol Nurs. 2010;10(2):231–239. Article PDF
6. Yang GS, Choe MA. Effet of anorexia and neuropathic pain induced by cisplatin on hindlimb muscles of rat. J Korean Acad Nurs. 2013;43(3):361–369. Article PubMed
7. Windebank AJ, Grisold W. Chemotherapy-induced neuropathy. J Peripher Nerv Syst. 2008;13(1):27–46. Article PubMed
8. Rosson GD. Chemotherapy-induced neuropathy. Clin Podiatr Med Surg. 2006;23(3):637–649. Article PubMed
9. Choe MA, An GJ. Effect of nitric oxide synthase inhibitor on hindlimb muscle in rats with neuropathic pain induced by unilateral peripheral nerve injury. J Korean Acad Nurs. 2011;41(4):520–527. Article PubMed
10. Oh PJ, Lee YJ. Predictors of fighting spirit or helplessness/hopelessness in people with cancer. J Korean Acad Nurs. 2008;38(2):270–277. Article
11. Wickham R. Chemotherapy-induced peripheral neuropathy: A review and implications for oncology nursing practice. Clin J Oncol Nurs. 2007;11(3):361–376. Article PubMed
12. Kim JH, Lee KM, Jeon MJ, Seol ME, Lee SH, Park JY. Symptom and interference of activities of daily living of chemotherapy-induced peripheral neuropathy in patients receiving taxanes and platinums. Asian Oncol Nurs. 2013;13(3):145–151. Article PDF
13. Kim HY, Kang JH, Song JE, Youn HJ. Chemotherapy-induced peripheral neuropathy and quality of life in breast cancer patients. Asian Oncol Nurs. 2013;13(4):222–230. Article PDF
14. Hwang WH. Assessment using CIPNAT for peripheral neuropathy in cancer patients undergoing chemotherapy[master's thesis]. Busan, Kosin University. 2013;1–57.
15. Huang TW, Lin CC. The mediating effects of depression on sleep disturbance and fatigue: Symptom clusters in patients with hepatocellular carcinoma. Cancer Nurs. 2009;32(5):398–403. PubMed
16. Kim JN, Lee R. A review of research on the psychosocial interventions for the cancer patients. Korean J Health Psychol. 2008;13:329–357.Article
17. Lee SY, Ham YH, Ok ON, Kim EJ, Kwon IG, Hwang MS, et al. The effects of foot reflexology on peripheral neuropathy, symptom distress, anxiety and depression in cancer patients treated with oxaliplatin. Asian Oncol Nurs. 2012;12(4):305–313. Article PDF
18. Raingruber B. The effectiveness of psychosocial interventions with cancer patients: An integrative review of the literature (2006-2011). ISRN Nurs. 2011;2011Article PDF
19. Shrock D, Palmer RF, Taylor B. Effects of a psychosocial intervention on survival among patients with stage I breast and prostate cancer: A matched case-control study. Altern Ther Health Med. 1999;5(3):49–55.
20. Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175–191. Article PubMed PDF
21. Oh SM, Min KJ, Park DB. A comparison of normal, depressed and anxious groups: A study on the standardization of the hospital anxiety and depressed scale for Koreans. J Korean Neuropsychiatr Assoc. 1999;38(2):289–296.
22. Kim H, Yoo HJ, Kim YJ, Han OS, Lee KH, Lee JH. Development and validation of Korean functional assessment cancer therapy-general (FACT-G). Korean J Clin Psychol. 2003;22:215–229.
23. Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51(6):1173–1182.Article PubMed
24. Lee IH. Easy flow regression analysis. Seoul: Hannarae; 2014. p. 313–316.
25. Yoo YS, Cho OK. Relationship between quality of life and nurseled bedside symptom evaluations in patients with chemotherapy-induced peripheral neuropathy. Asian Nurs Res. 2014;8(1):36–41. Article
26. Baek YA. The correlation among symptoms, anxiety, depression and quality of life in patients with colorectal cancer undergoing chemotherapy[master's thesis]. Seoul, Seoul University. 2013;1–80.
27. Choi KS, Park JA, Lee JH. The effect of symptom experience and resilience on quality of life in patients with colorectal cancers. Asian Oncol Nurs. 2012;12(1):61–68. Article PDF
28. Jeong JY, So HS, Hong JE, Chae MJ, Han GH. Related factors to quality of life among hospitalized cancer patients undergoing chemotherapy. Asian Oncol Nurs. 2012;12(1):84–91. Article PDF
29. Tsunoda A, Nakao K, Hiratsuka K, Yasuda N, Shibusawa M, Kusano M. Anxiety, depression and quality of life in colorectal cancer patients. Int J Clin Oncol. 2006;10(6):411–417. Article PDF
30. So WK, Marsh G, Ling WM, Leung FY, Lo JC, Yeung M, et al. The symptom cluster of fatigue, pain, anxiety, and depression and the effect on the quality of life of women receiving treatment for breast cancer: A multicenter study. Oncol Nurs Forum. 2009;36(4):E205–E214. Article PubMed
31. Avis NE, Crawford S, Manuel J. Quality of life among younger women with breast cancer. J Clin Oncol. 2005;23(15):3322–3330.Article PubMed

Figure 1

Mediating effect of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life.

Table 1

Disturbance in ADL, Psychological Distress, and Quality of Life according to General Characteristics of the Participants (N=130)

^*Vinka-alkaloid, vincristine, velcade; a, b=Scheffé test; CIPN=Chemotherapy-induced peripheral neuropathy.

Table 2

Level of Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Depression, Anxiety, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 3

Relationships among Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Psychological Distress, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 4

Mediating Effect of Psychological Distress in the Relationship between Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy and Quality of Life (N=130)

ADL=Activities of daily living; QoL=Quality of life.

Figure & Data

REFERENCES

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Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress

J Korean Acad Nurs. 2015;45(5):661-670. Published online October 30, 2015

DOI: https://doi.org/10.4040/jkan.2015.45.5.661

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Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress

Figure 1 Mediating effect of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life.

Figure 1

Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress

Table 1

Disturbance in ADL, Psychological Distress, and Quality of Life according to General Characteristics of the Participants (N=130)

^*Vinka-alkaloid, vincristine, velcade; a, b=Scheffé test; CIPN=Chemotherapy-induced peripheral neuropathy.

Table 2

Level of Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Depression, Anxiety, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 3

Relationships among Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Psychological Distress, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 4

Mediating Effect of Psychological Distress in the Relationship between Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy and Quality of Life (N=130)

ADL=Activities of daily living; QoL=Quality of life.

Table 1 Disturbance in ADL, Psychological Distress, and Quality of Life according to General Characteristics of the Participants (N=130)

^*Vinka-alkaloid, vincristine, velcade; a, b=Scheffé test; CIPN=Chemotherapy-induced peripheral neuropathy.

Table 2 Level of Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Depression, Anxiety, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 3 Relationships among Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Psychological Distress, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 4 Mediating Effect of Psychological Distress in the Relationship between Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy and Quality of Life (N=130)