Kyung Yeon Kim; Seung Hee Lee; Jeong Hye Kim; Pok Ja Oh

doi:10.4040/jkan.2015.45.5.661

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Original Article
Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress: Kyung Yeon Kim, Seung Hee Lee, Jeong Hye Kim, Pok Ja Oh; Journal of Korean Academy of Nursing 2015;45(5):661-670.
DOI: https://doi.org/10.4040/jkan.2015.45.5.661
Published online: October 30, 2015

¹Korea Institude of Radiological & Medical Science, Seoul, Korea.

²Department of Clinical Nursing, University of Ulsan, Seoul, Korea.

³Department of Nursing, Sahmyook University, Seoul, Korea.

Address reprint requests to: Oh, Pok-Ja. Department of Nursing, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 01795, Korea. Tel: +82-2-3399-1589, Fax: +82-2-3399-1594, ohpj@syu.ac.kr

• Received: February 11, 2015 • Revised: February 17, 2015 • Accepted: June 5, 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution NoDerivs License. (http://creativecommons.org/licenses/by-nd/4.0/) If the original work is properly cited and retained without any modification or reproduction, it can be used and re-distributed in any format and medium.

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Abstract
REFERENCES

Abstract

Purpose
The purpose of this study was to examine the mediation of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life in order to provide a basis for planning nursing interventions to improve the quality of life in cancer patients.
Methods
A purposive sample of 130 patients treated with chemotherapy were recruited in the cross-sectional survey design. Data were collected using self-report questionnaires. The instruments were the Chemotherapy Induced Peripheral Neuropathy Assessment Tool (CIPNAT), Hospital Anxiety Depression Scale (HADS), and Functional Assessment of Cancer Therapy-General (FACT-G).
Results
The mean score for disturbance in ADL from chemotherapy induced peripheral neuropathy was 3.30. Overall quality of life was 2.48. The mean score was 1.04 for psychological distress. The prevalence was 35.4% for anxiety and 47.7% for depression. There were significant correlations among the three variables, disturbance in ADL from chemotherapy induced peripheral neuropathy, psychosocial distress, and quality of life. Psychosocial distress had a complete mediating effect (β= -.74, p <.001) in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life (Sobel test: Z= -6.11, p <.001).
Conclusion
Based on the findings of this study, nursing intervention programs focusing on disturbance of ADL management, and decrease of psychological distress are highly recommended to improve quality of life in cancer patients.
Keywords: Quality of life; Peripheral neuropathy; Neoplasm; Depression

REFERENCES

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Figure 1

Mediating effect of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life.

Table 1

Disturbance in ADL, Psychological Distress, and Quality of Life according to General Characteristics of the Participants (N=130)

^*Vinka-alkaloid, vincristine, velcade; a, b=Scheffé test; CIPN=Chemotherapy-induced peripheral neuropathy.

Table 2

Level of Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Depression, Anxiety, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 3

Relationships among Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Psychological Distress, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 4

Mediating Effect of Psychological Distress in the Relationship between Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy and Quality of Life (N=130)

ADL=Activities of daily living; QoL=Quality of life.

Figure & Data

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Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress

J Korean Acad Nurs. 2015;45(5):661-670. Published online October 30, 2015

DOI: https://doi.org/10.4040/jkan.2015.45.5.661

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Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress

Figure 1 Mediating effect of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life.

Figure 1

Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress

Table 1

Disturbance in ADL, Psychological Distress, and Quality of Life according to General Characteristics of the Participants (N=130)

^*Vinka-alkaloid, vincristine, velcade; a, b=Scheffé test; CIPN=Chemotherapy-induced peripheral neuropathy.

Table 2

Level of Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Depression, Anxiety, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 3

Relationships among Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Psychological Distress, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 4

Mediating Effect of Psychological Distress in the Relationship between Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy and Quality of Life (N=130)

ADL=Activities of daily living; QoL=Quality of life.

Table 1 Disturbance in ADL, Psychological Distress, and Quality of Life according to General Characteristics of the Participants (N=130)

^*Vinka-alkaloid, vincristine, velcade; a, b=Scheffé test; CIPN=Chemotherapy-induced peripheral neuropathy.

Table 2 Level of Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Depression, Anxiety, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 3 Relationships among Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Psychological Distress, and Quality of Life (N=130)

ADL=Activities of daily living.

Table 4 Mediating Effect of Psychological Distress in the Relationship between Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy and Quality of Life (N=130)