Ok-Hee Cho; Yang-Sook Yoo; Suk-Kyun Yang

doi:10.4040/jkan.2012.42.2.207

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Original Article
Depression and Risk Factors in Patients with Crohn's Disease: Ok-Hee Cho, Yang-Sook Yoo, Suk-Kyun Yang; Journal of Korean Academy of Nursing 2012;42(2):207-216.
DOI: https://doi.org/10.4040/jkan.2012.42.2.207
Published online: April 30, 2012

¹Full-time Lecturer, College of Nursing, Jeju National University, Jeju, Korea.

²Professor, College of Nursing, The Catholic University of Korea, Seoul, Korea.

³Professor, Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Address reprint requests to: Yoo, Yang-Sook. College of Nursing, Jeju National University, 505 Banpo-dong, Seocho-gu, Seoul 137-701, Korea. Tel: +82-2-2258-7411, Fax: +82-2-2258-7772, ysyoo@catholic.ac.kr

• Received: July 8, 2011 • Accepted: April 26, 2012

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Abstract
NOTES
REFERENCES

Abstract

Purpose
This study was conducted to determine the risk factors among patients with depression with Crohn's disease.
Methods
Data were collected by questionnaire from 276 patients who were diagnosed with Crohn's disease at a tertiary hospital located in Seoul. Measurements included patients' demographic characteristics, clinical characteristics, depression level, and health-related quality of life. Data were analyzed using t-test, χ²-test, Wilcoxon rank sum test, and logistic regression analyses.
Results
The incidence rate of depression (BDI-II≥14scores) was 31.9% (n=88). Univariate analysis revealed that being a woman, school graduation status, economic status (low), BMI(<18.5Kg/m²), disease duration (≥3 years), CDAI (≥150 scores), frequency of hospital admission (≥2), extra-intestinal manifestation (arthralgia, stomatitis), administration of 5-aminosalicylic acid, and disease related quality of life (SIBDQ<50 scores) were associated with depression. Multivariate analysis revealed that economic status (low), school graduation status, and quality of life (SIBDQ<50 scores) were more likely to report high level of depression.
Conclusion
Future research should consider managing depression as an essential component of comprehensive care for patients with Crohn's disease. In addition, further research is needed to develop strategies to better improve quality of life among patients with Crohn's disease who are depressed.
Keywords: Crohn's disease; Depression; Risk factors

The authors wishes to acknowledge the financial support of the Catholic Medical Center Research Foundation made in the program year of 2009.

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Table 1

Comparison of General Characteristics between Patients with Depression and with no Depression (N=276)

BMI=Body mass index.

Table 2

Comparison Disease-related Characteristics between Patients with Depression and with no Depression (N=276)

CDAI=Crohn's disease activity index;

^* Fisher's exact test; ^†Values are median (range); ^‡Subjects may select more than one item.

Table 3

Comparison Health-related Quality of Life between Patients with Depression and with no Depression (N=276)

Table 4

Risk Factors for Depression by Univariate Analysis

CDAI=Crohn's Disease Activity Index; OR=Odds ratio; 95% CI=95% confidence interval; SIBDQ=Short Inflammatory Bowel Disease Questionnaire.

Table 5

Risk Factors for Depression by Multivariate Analysis

SIBDQ=Short Inflammatory Bowel Disease Questionnaire; OR=Odds ratio; 95% CI=95% confidence interval.

Figure & Data

REFERENCES

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Depression and Risk Factors in Patients with Crohn's Disease

J Korean Acad Nurs. 2012;42(2):207-216. Published online April 30, 2012

DOI: https://doi.org/10.4040/jkan.2012.42.2.207

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Depression and Risk Factors in Patients with Crohn's Disease

Table 1

Comparison of General Characteristics between Patients with Depression and with no Depression (N=276)

BMI=Body mass index.

Table 2

Comparison Disease-related Characteristics between Patients with Depression and with no Depression (N=276)

CDAI=Crohn's disease activity index;

^* Fisher's exact test; ^†Values are median (range); ^‡Subjects may select more than one item.

Table 3

Comparison Health-related Quality of Life between Patients with Depression and with no Depression (N=276)

Table 4

Risk Factors for Depression by Univariate Analysis

CDAI=Crohn's Disease Activity Index; OR=Odds ratio; 95% CI=95% confidence interval; SIBDQ=Short Inflammatory Bowel Disease Questionnaire.

Table 5

Risk Factors for Depression by Multivariate Analysis

SIBDQ=Short Inflammatory Bowel Disease Questionnaire; OR=Odds ratio; 95% CI=95% confidence interval.

Table 1 Comparison of General Characteristics between Patients with Depression and with no Depression (N=276)

BMI=Body mass index.

Table 2 Comparison Disease-related Characteristics between Patients with Depression and with no Depression (N=276)

CDAI=Crohn's disease activity index;

^* Fisher's exact test; ^†Values are median (range); ^‡Subjects may select more than one item.

Table 3 Comparison Health-related Quality of Life between Patients with Depression and with no Depression (N=276)

Table 4 Risk Factors for Depression by Univariate Analysis

CDAI=Crohn's Disease Activity Index; OR=Odds ratio; 95% CI=95% confidence interval; SIBDQ=Short Inflammatory Bowel Disease Questionnaire.

Table 5 Risk Factors for Depression by Multivariate Analysis

SIBDQ=Short Inflammatory Bowel Disease Questionnaire; OR=Odds ratio; 95% CI=95% confidence interval.