Jin Il Kim; Myoung-Ae Choe

doi:10.4040/jkan.2009.39.3.393

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Original Article
Effects of Unilateral Sciatic Nerve Injury on Unaffected Hindlimb Muscles of Rats: Jin Il Kim, Myoung-Ae Choe; Journal of Korean Academy of Nursing 2009;39(3):393-400.
DOI: https://doi.org/10.4040/jkan.2009.39.3.393
Published online: June 29, 2009

¹Staff Member, Health Insurance Review and Assessment Service, Seoul, Korea.

²Professor, College of Nursing, Seoul National University, Seoul, Korea.

Address reprint requests to: Kim, Jin Il. Health Insurance Review and Assessment Service, 1586-7 Seocho 3-dong, Seocho-gu, Seoul 137-706, Korea. Tel: 82-2-2182-2379, Fax: 82-2-585-4337, neoreva@hanmail.net

• Received: December 19, 2008 • Accepted: May 26, 2009

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Abstract
NOTES
REFERENCES

Abstract

Purpose
The purpose of this study was to examine the effects of unilateral sciatic nerve injury on unaffected hindlimb muscles of rats.
Methods
Adult male Sprague-Dawley rats were assigned to one of three groups: control (C) group (n=10) that had no procedures, sham (S) group (n=10) that underwent sham left sciatic nerve transection, and sciatic nerve transection (SNT) group (n=9) that underwent left sciatic nerve transection. At 15 days rats were anesthetized, and the soleus, plantaris and gastrocnemius muscles were dissected.
Results
Muscle weight of the unaffected plantaris muscle in the SNT group was significantly lower than in the other two groups. Type II fiber cross-sectional areas of the unaffected plantaris and gastrocnemius muscles in the SNT group were significantly smaller than in the other two groups. The decrease of muscle weights and Type I, II fiber cross-sectional areas of the unaffected three muscles in the SNT group were significantly less than that of the affected three muscles.
Conclusion
Hindlimb muscle atrophy occurs in the unaffected side after unilateral sciatic nerve injury, with changes in the plantaris and gastrocnemius muscle being more apparent than changes in the soleus muscle. These results have implications for nursing care, in the need to assess degree of muscle atrophy in unaffected muscles as well as affected muscles.
Keywords: Sciatic nerve injury; Rats; Hindlimb; Muscular atrophy

This article is a part of master's thesis.

REFERENCES

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Table 1

Preweight and Postweight among the Groups

^*Significant difference between Preweight & Postweight (p<.001); ^†Significant difference among the Groups (p<.05); ^‡Significant difference between C & SNT (p<.05).

C=control; S=sham; SNT=sciatic nerve transection.

Table 2

Total Diet Intake among the Groups

C=control; S=sham; SNT=sciatic nerve transection.

Table 3

Three Component Patterns of Activity among the Groups

^*Significant difference among the Groups (p<.05); ^†Significant difference between C & SNT (p<.05); ^‡Significant difference between S & SNT (p<.05).

C=control; S=sham; SNT=sciatic nerve transection.

Table 4

Muscle Weight of Hindlimb Muscles of Control, Sham and Sciatic Nerve Transection Groups

^*Significant difference among the Groups (p<.05); ^†Significant difference among the Groups (p<.001); ^‡Significant difference between C & SNT (p<.05); ^§Significant difference between C & SNT (p<.001); ^∥Significant difference between S & SNT (p<.05); ^¶Significant difference between S & SNT (p<.001); ^**Significant difference between the affected & unaffected sides (p<.001).

C=control; S=sham; SNT=sciatic nerve transection.

Table 5

Cross-Sectional Area of Hindlimb Muscles of Control, Sham and Sciatic Nerve Transection Groups

C=control; S=sham; SNT=sciatic nerve transection.

Figure & Data

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Effects of Unilateral Sciatic Nerve Injury on Unaffected Hindlimb Muscles of Rats

J Korean Acad Nurs. 2009;39(3):393-400. Published online June 29, 2009

DOI: https://doi.org/10.4040/jkan.2009.39.3.393

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Effects of Unilateral Sciatic Nerve Injury on Unaffected Hindlimb Muscles of Rats

Table 1

Preweight and Postweight among the Groups

^*Significant difference between Preweight & Postweight (p<.001); ^†Significant difference among the Groups (p<.05); ^‡Significant difference between C & SNT (p<.05).

C=control; S=sham; SNT=sciatic nerve transection.

Table 2

Total Diet Intake among the Groups

C=control; S=sham; SNT=sciatic nerve transection.

Table 3

Three Component Patterns of Activity among the Groups

^*Significant difference among the Groups (p<.05); ^†Significant difference between C & SNT (p<.05); ^‡Significant difference between S & SNT (p<.05).

C=control; S=sham; SNT=sciatic nerve transection.

Table 4

Muscle Weight of Hindlimb Muscles of Control, Sham and Sciatic Nerve Transection Groups

C=control; S=sham; SNT=sciatic nerve transection.

Table 5

Cross-Sectional Area of Hindlimb Muscles of Control, Sham and Sciatic Nerve Transection Groups

C=control; S=sham; SNT=sciatic nerve transection.

Table 1 Preweight and Postweight among the Groups

^*Significant difference between Preweight & Postweight (p<.001); ^†Significant difference among the Groups (p<.05); ^‡Significant difference between C & SNT (p<.05).

C=control; S=sham; SNT=sciatic nerve transection.

Table 2 Total Diet Intake among the Groups

C=control; S=sham; SNT=sciatic nerve transection.

Table 3 Three Component Patterns of Activity among the Groups

^*Significant difference among the Groups (p<.05); ^†Significant difference between C & SNT (p<.05); ^‡Significant difference between S & SNT (p<.05).

C=control; S=sham; SNT=sciatic nerve transection.

Table 4 Muscle Weight of Hindlimb Muscles of Control, Sham and Sciatic Nerve Transection Groups

C=control; S=sham; SNT=sciatic nerve transection.

Table 5 Cross-Sectional Area of Hindlimb Muscles of Control, Sham and Sciatic Nerve Transection Groups