Abstract

• Purpose
  The purpose of this study was to examine the effects of cerebral ischemia on Type I(soleus) and Type II(plantaris, gastrocnemius) muscles, and to determine the effects of isometric contraction training by electrostimulation on Type I andII muscles in cerebral ischemia model rats.
• Method
  Twenty-five male Sprague-Dawley rats were randomly divided into four groups: ST(stroke), STES(stroke+electrostimulation), SH(sham) and SHES (sham+electrostimulation). The ST and STES groups received a transient right middle cerebral artery occlusion operation. The SH and SHES groups received a sham operation. The STES and SHES groups had daily isometric contraction training by electrostimulation(100Hz, 45mA, 7.5V) on hindlimb muscles for 7days.
• Result
  Plantaris and gastrocenmius muscle weight, myofibrillar protein contents of soleus and gastrocnemius, and the muscle fiber cross-sectional area of gastrocnemius in the ST group significantly decreased compared with the SH group. Soleus, plantaris, gastrocnemius muscle weight, myofibrillar protein contents of soleus and gastrocnemius, and the Type I muscle fiber cross-sectional area of soleus and the Type II muscle fiber cross-sectional area of gastrocnemius in the STES group significantly increased compared with the ST group.
• Conclusion
  Hindlimb muscle atrophy occurs after acute stroke and isometric contraction training by electrostimulation during early stages of a stroke attenuates muscle atrophy of Type I and Type II muscles.
• Keywords: Stroke; Muscle atrophy; Type I; II muscles; Electrostimulation; Cerebral ischemia

Figure & Data

REFERENCES

Citations

Citations to this article as recorded by  

• Use of Animals for Nursing Research in Korea
  Hae Young Yoo
  Journal of Korean Biological Nursing Science.2015; 17(4): 324.     CrossRef
• Hindlimb Muscle Atrophy Occurs From Short-Term Undernutrition in Rats
  Jee Yoon Kim
  Biological Research For Nursing.2013; 15(4): 459.     CrossRef