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Research Paper
- Effects of a theory-based climate change adaptation education program on oxidative stress and psychosocial outcomes among women of reproductive age: a randomized controlled trial
- Su Ji Heo, Ju Hee Kim
- Received May 8, 2026 Accepted October 8, 2026 Published online November 13, 2026
- DOI: https://doi.org/10.4040/jkan.26077 [Epub ahead of print]
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Abstract
PDF - Purpose
This study evaluated the effects of WECARE (Women’s Education Program for Climate Change Adaptation in Reproductive Age), a 4-week intervention based on Roy’s Adaptation Model, on oxidative stress biomarkers and psychosocial adaptation outcomes among women of reproductive age.
Methods
This randomized controlled trial was conducted at a university in Seoul, South Korea, with 50 women of reproductive age included in the final analysis (intervention, n=25; control, n=25). WECARE combined face-to-face sessions, digital card news, and short-form videos; the control group received standard written educational materials. Psychosocial outcomes were assessed at baseline, immediately after the intervention, and at a 2-week follow-up; biomarkers were assessed at baseline and follow-up. The trial was registered with the Clinical Research Information Service (KCT0009821).
Results
Ranked analysis of covariance revealed a significant between-group difference in urinary 8-hydroxydeoxyguanosine (8-OHdG) after adjustment for baseline values (F=7.46, p=.009, partial η²=.14). Levels of 8-OHdG decreased in the intervention group (p<.001) and increased in the control group (p=.042), although these findings warrant cautious interpretation because of the baseline imbalance. Malondialdehyde showed no significant within- or between-group differences. Analysis using generalized estimating equations revealed significant group-by-time interactions for positive psychological capital (χ²=31.57, p<.001), action competence regarding climate change (χ²=19.04, p<.001), and social support (χ²=20.70, p<.001). Improvements in all three psychosocial outcomes were sustained at the 2-week follow-up.
Conclusion
WECARE was associated with a between-group difference in urinary 8-OHdG and improvements in psychosocial adaptation outcomes among women of reproductive age. These findings support integrating climate change adaptation into nursing education curricula.
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