Gee Su Yang; Myoung-Ae Choe

doi:10.4040/jkan.2013.43.3.361

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Original Article
Effect of Anorexia and Neuropathic Pain Induced by Cisplatin on Hindlimb Muscles of Rat: Gee Su Yang, Myoung-Ae Choe; Journal of Korean Academy of Nursing 2013;43(3):361-369.
DOI: https://doi.org/10.4040/jkan.2013.43.3.361
Published online: June 28, 2013

¹School of Nursing, University of Maryland, Baltimore, MD, U.S.A.

²College of Nursing, Seoul National University, Seoul, Korea.

Address reprint requests to: Yang, Gee Su. School of Nursing, University of Maryland, 655 West Lombard Street, Room 404, Baltimore, MD 21201, U.S.A. Tel: +1-310-424-0756, Fax: +1-410-706-3769, gsyang@umaryland.edu

• Received: September 10, 2012 • Accepted: March 22, 2013

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Abstract
NOTES
REFERENCES

Abstract

Purpose
The purpose of this study was to examine the effect of anorexia and neuropathic pain induced by cisplatin on hindlimb muscles of rats.
Methods
Adult male Sprague-Dawley rats were divided into two groups, a cisplatin-treated group (n=10) and a control group (n=10). In the cisplatin-treated group, cisplatin at a dose of 2 mg/kg was injected intraperitoneally two times a week up to a cumulative dose of 20 mg/kg over 5 weeks, and in the control group saline (0.9% NaCl) was injected intraperitoneally at the same dose and duration as the cisplatin-treated group. At 34 days all rats were anesthetized, after which the soleus and plantaris muscles were dissected. Withdrawal threshold, body weight, food intake, activity, muscle weight, Type I and II fiber cross-sectional areas and myofibrillar protein content of the dissected muscles were determined.
Results
Compared with the control group, the cisplatin-treated group showed significant decreases (p<.05) in withdrawal threshold, activity, food intake, body weight, Type I and II fiber cross-sectional areas, myofibrillar protein content and weight of the soleus and plantaris muscles.
Conclusion
Muscular atrophy in hindlimb occurs due to anorexia and neuropathic pain induced by the cisplatin treatment.
Keywords: Cisplatin; Neuropathic pain; Anorexia; Muscular atrophy

This manuscript is based on a part of the first author's master's thesis from Seoul National University.

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Figure 1

Changes of withdrawal thresholds in the control and cisplatin groups.

Table 1

Experimental Procedures

Table 2

Experimental Results in the Control and Cisplatin Groups

NP=Neuropathic pain; ^*Significantly different between the control and cisplatin groups (p<.05).

Figure & Data

REFERENCES

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Effect of Anorexia and Neuropathic Pain Induced by Cisplatin on Hindlimb Muscles of Rat

J Korean Acad Nurs. 2013;43(3):361-369. Published online June 28, 2013

DOI: https://doi.org/10.4040/jkan.2013.43.3.361

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Effect of Anorexia and Neuropathic Pain Induced by Cisplatin on Hindlimb Muscles of Rat

Figure 1 Changes of withdrawal thresholds in the control and cisplatin groups.

Figure 1

Effect of Anorexia and Neuropathic Pain Induced by Cisplatin on Hindlimb Muscles of Rat

Table 1

Experimental Procedures

Table 2

Experimental Results in the Control and Cisplatin Groups

NP=Neuropathic pain; ^*Significantly different between the control and cisplatin groups (p<.05).

Table 1 Experimental Procedures

Table 2 Experimental Results in the Control and Cisplatin Groups

NP=Neuropathic pain; ^*Significantly different between the control and cisplatin groups (p<.05).