Skip Navigation
Skip to contents

J Korean Acad Nurs : Journal of Korean Academy of Nursing

Search
Advanced Search
OPEN ACCESS
mobile search button mobile menu button

Articles

Page Path
HOME > J Korean Acad Nurs > Volume 42(3); 2012 > Article
Original Article
Health-related Quality of Life in Korean Patients with Rheumatoid Arthritis: Association with Pain, Disease Activity, Disability in Activities of Daily Living and Depression
Dong Choon Uhm, Eun Sook Nam, Ho Yeon Lee, Eun Bong Lee, Young Im Yoon, Gong Ju Chai
Journal of Korean Academy of Nursing 2012;42(3):434-442.
DOI: https://doi.org/10.4040/jkan.2012.42.3.434
Published online: June 29, 2012

1Assistant Professor, Department of Emergency Medical Technician, Daejeon University, Daejeon, South Korea.

2Professor, Department of Nursing, Health Care Research Center, Kangwon National University, Chuncheon, South Korea.

3Head Nurse, Seoul Medical Center, Seoul, South Korea.

4Professor, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

5Nurse, Seoul National University Hospital, Seoul, South Korea.

6Nurse, Chuncheon National Hospital, Chuncheon, South Korea.

Address reprint requests to: Nam, Eun Sook. Department of Nursing, Gangwon National University, Hyoja 2(i)-dong, Chuncheon-si, Gangwon-do, SEOUL 200-701 Rep. of KOREA. Tel: +82-33-250-8883, Fax: +82-33-242-8840, esnam7@hanmail.net
• Received: April 7, 2011   • Accepted: May 30, 2012

© 2012 Korean Society of Nursing Science

  • 19 Views
  • 1 Download
prev next
Full Article

Download PDF Download PDF

  • Purpose
    The purpose of this predictive study was to identify factors affecting health related quality of life (HRQoL) in patients with rheumatoid arthritis (RA).
  • Methods
    The participants in this study were 131 patients with RA who were recruited from the outpatient clinic of a university hospital in Seoul. Disease activity in rheumatoid arthritis was evaluated by calculating the Disease Activity Score 28. Disability in activities of daily living (ADL) was assessed with the Korean Health Assessment Questionnaire, and depression with The Center for Epidemiologic Studies Depression Scale. HRQoL was evaluated using The Short Form 36 Health Survey. Data were analyzed using descriptive statistics, correlation, and hierarchical multiple regression.
  • Results
    Pain, disability in ADL, disease activity, and depression correlated negatively with physical and mental dimensions of HRQoL. But hierachical multiple regression analysis revealed that disability in ADL and depression were the only variables negatively influencing physical and mental QoL after adjustment for influences of sociodemographic variables.
  • Conclusion
    Results of this study suggest that disability in ADL and depression, rather than disease activity and pain have profound effects on HRQoL in patients with RA. Further studies are needed to assess the predictive ability of disease activity and pain on HRQoL in this population.
  • Keywords: Rheumatoid arthritis; Health related quality of life; Pain; Disability in ADL; Depression
  • 1. Bae SC, Cook EF, Kim SY. Psychometric evaluation of a Korean health assessment questionnaire for clinical research. Journal of Rheumatology. 1998;25:1975–1979.PubMed
  • 2. Benitha R, Tikly M. Functional disability and health-related quality of life in South Africans with rheumatoid arthritis and systemic lupus erythematosus. Clinical Rheumatology. 2007;26:24–29. http://dx.doi.org/10.1007/s10067-006-0215-4.ArticlePubMedPDF
  • 3. Chon KK, Choi SC, Yang BC. Integrated adaptation of CES-D in Korea. Korean Journal of Health Psychology. 2001;6(1):59–76.
  • 4. Fries JF, Spitz P, Kraines RG, Holman HR. Measurement of patient outcome in arthritis. Arthritis and Rheumatism. 1980;23:137–145. http://dx.doi.org/10.1002/art.1780230202.Article
  • 5. Haroon N, Aggarwal A, Lawrence A, Agarwal V, Misra R. Impact of rheumatoid arthritis on quality of life. Modern Rheumatology. 2007;17:290–295. http://dx.doi.org/10.1007/s10165-007-0604-9.ArticlePubMed
  • 6. Hong SW. Factors influencing health-related quality of life in Korean medicaid beneficiaries. Journal of Korean Academy of Nursing. 2009;39:480–489. http://dx.doi.org/10.4040/jkan.2009.39.4.480.ArticlePubMed
  • 7. Jakobsson U, Hallberg IR. Pain and quality of life among older people with rheumatoid arthritis and/or osteoarthritis: A literature review. Journal of Clinical Nursing. 2002;11(4):430–443. http://dx.doi.org/10.1046/j.1365-2702.2002.00624.x.ArticlePubMed
  • 8. Kim EJ. Influencing factors on quality of life in patients with rheumatoid arthritis. 2010;Busan, Inje University. Unpublished master's thesis.
  • 9. Koh SB, Chang SJ, Kang MG, Cha BS, Park JK. Reliability and validity on measurement instrument for health status assessment in occupational worker. Korean Journal of Preventive Medicine. 1997;30:251–266.
  • 10. Kojima M, Kojima T, Ishiguro N, Oguchi T, Oba M, Tsuchiya H, et al. Psychosocial factors, disease status, and quality of life in patients with rheumatoid arthritis. Journal of Psychosomatic Research. 2009;67:425–431. http://dx.doi.org/10.1016/j.jpsychores.2009.01.001.ArticlePubMed
  • 11. Lee DM, Weinblatt ME. Rheumatoid arthritis. Lancet. 2001;358:903–911. http://dx.doi.org/10.1016/S0140-6736(01)06075-5.ArticlePubMed
  • 12. Lee HJ, Choi-Kwon S. Quality of life and related factors in patients with dizziness. Journal of Korean Academy of Nursing. 2009;39:751–758. http://dx.doi.org/10.4040/jkan.2009.39.5.751.PubMed
  • 13. Lu SR, Lin HY, Lin KC, Lin HR. Quality of life in middle-aged and older Taiwanese patients with rheumatoid arthritis. Journal of Nursing Research. 2008;16:121–130. http://dx.doi.org/10.1097/01.JNR.0000387297.29796.ad.Article
  • 14. Nichol MB, Zhang L. Depression and health-related quality of life in patients with rheumatoid arthritis. Expert Review of Pharmacoeconomics and Outcomes Research. 2005;5:645–653. http://dx.doi.org/10.1586/14737167.5.5.645.ArticlePubMed
  • 15. Oh HJ. Investigation on factors influencing the quality of life of arthritis patients. Korean Journal of Adult Nursing. 2000;12:431–451.
  • 16. Oh HS, Kim YR. A structural model for quality of life in individuals with rheumatoid arthritis. The Journal of Nurses Academic Society. 1997;27:614–626.ArticlePDF
  • 17. Park HS. A study on knowledge, self efficacy and quality of life in rheumatic arthritis patients. Korean Journal of Rural Medicine. 2000;25:275–292.
  • 18. Park SY, Nam YW, Baek MW. The relationships among self care agency, family support, quality of life in patients with rheumatoid arthritis. Journal of Muscle and Joint Health. 2000;7:281–293.
  • 19. Park SY, Park JS. The influence of family support on the activities of daily living and quality of life among patients with rheumatoid arthritis. Journal of Muscle and Joint Health. 2000;7:63–76.
  • 20. Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis and Rheumatism. 1995;38:44–48. http://dx.doi.org/10.1002/art.1780380107.ArticlePDF
  • 21. Radloff LS. The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measurement. 1977;1:385–401. http://dx.doi.org/10.1177/014662167700100306.ArticlePDF
  • 22. Rupp I, Boshuizen HC, Dinant HJ, Jacobi CE, van den Bos GAM. Disability and health-related quality of life among patients with rheumatoid arthritis: Association with radiographic joint damage, disease activity, pain, and depressive symptoms. Scandinavian Journal of Rheumatology. 2006;35:175–181. http://dx.doi.org/10.1080/03009740500343260.ArticlePubMed
  • 23. Ruta DA, Hurst NP, Kind P, Hunter M, Stubbings A. Measuring health status in British patients with rheumatoid arthritis: Reliability, validity and responsiveness of the short form 36-item health survey(SF-36). British Journal of Rheumatology. 1998;37:425–436. http://dx.doi.org/10.1093/rheumatology/37.4.425.ArticlePubMed
  • 24. Salaffi F, Cimmino MA, Leardini G, Gasparini S, Grassi W. Disease activity assessment of rheumatoid arthritis in daily practice: Validity, internal consistency, reliability and congruency of the Disease Activity Score including 28 joints (DAS28) compared with the Clinical Disease Activity Index (CDAI). Clinical and Experimental Rheumatology. 2009;27:552–559.PubMed
  • 25. Suh MJ, Kim KS, Roh KH. Analysis study of quality of life in home stayed arthritis patients. Journal of Rheumatology Health. 2002;9:166–176.
  • 26. Tander B, Cengiz K, Alayli G, Ilhanli I, Canbaz S, Canturk F. A comparative evaluation of health related quality of life and depression in patients with fibromyalgia syndrome and rheumatoid arthritis. Rheumatology International. 2008;28:859–865. http://dx.doi.org/10.1007/s00296-008-0551-6.ArticlePubMedPDF
  • 27. Ware JE jr, Sherbourne CD. The MOS 36-item short-form health survey(SF-36): I. conceptual framework and item selection. Medical Care. 1992;30:473–483.ArticlePubMed
  • 28. Ware JE. SF-36 Health survey. Manual & interpretation guide. 1993;Boston, MA, The Health Institute.
Table 1
Health related Quality of Life by Sociodemographic Variables (N=131)
jkan-42-434-i001.jpg

QOL=Quality of life.

*p<.05; **p<.01; †The same letters indicate nonsignificant difference between groups based on Tukey's multiple comparison test.

Table 2
Clinical, Psychological Characteristics and Quality of Life (N=131)
jkan-42-434-i002.jpg

SD=Standard deviation; RA=Rheumatoid arthritis; ADL=Activities of daily living; KHAQ=Korean health assessment questionnaire; DAS28-ESR= Disease activity score 28-erythrocyte sedimentation rate; VAS=Visual analogue scale; QOL=Quality of life; CES-D=The center for epidemiologic studies-depression scale; SF-36=The medical outcomes study short form 36 health survey.

Table 3
Correlation Coefficients of Study Variables with Physical and Mental QOL (N=131)
jkan-42-434-i003.jpg

RA=Rheumatoid arthritis; QOL=Quality of life; ADL=Activities of daily living.

Table 4
Factors Predicting Physical QOL (N=131)
jkan-42-434-i004.jpg

a=Dummy coded (married=1, single=0); b=Dummy coded (employed=1, unemployed=0); c=Dummy coded (Catholic or Protestant=1, none or Buddhist=0); VAS=Visual analogue scale; QOL=Quality of life; ADL=Activities of daily living; DAS28-ESR=Disease Activity Score 28-Erythrocyte Sedimentation Rate; KHAQ=Korean health assessment questionnaire; RA=Rheumatoid arthritis; CES-D=The Center for Epidemiologic Studies-Depression Scale.

Table 5
Factors Predicting Mental QOL (N=131)
jkan-42-434-i005.jpg

a=dummy coded (married=1, single=0); b=dummy coded (Catholic or Protestant=1, none or Buddhist=0); c=dummy coded (employed=1, unemployed=0); VAS=Visual analogue scale; QOL=Quality of life; ADL=Activities of daily living; DAS28-ESR=Disease Activity Score 28-Erythrocyte Sedimentation Rate; KHAQ=Korean health assessment questionnaire; RA=Rheumatoid arthritis; CES-D=The Center for Epidemiologic Studies-Depression Scale.

Figure & Data

REFERENCES

    Citations

    Citations to this article as recorded by  

      • Cite
        CITE
        export Copy Download
        Close
        Download Citation
        Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.
        Format:
        • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
        • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
        Include:
        • Citation for the content below
        Health-related Quality of Life in Korean Patients with Rheumatoid Arthritis: Association with Pain, Disease Activity, Disability in Activities of Daily Living and Depression
        J Korean Acad Nurs. 2012;42(3):434-442.   Published online June 29, 2012
        DOI: https://doi.org/10.4040/jkan.2012.42.3.434
        Close
      • XML DownloadXML Download
      We recommend
      Health-related Quality of Life in Korean Patients with Rheumatoid Arthritis: Association with Pain, Disease Activity, Disability in Activities of Daily Living and Depression
      Health-related Quality of Life in Korean Patients with Rheumatoid Arthritis: Association with Pain, Disease Activity, Disability in Activities of Daily Living and Depression

      Health related Quality of Life by Sociodemographic Variables (N=131)

      QOL=Quality of life.

      *p<.05; **p<.01; †The same letters indicate nonsignificant difference between groups based on Tukey's multiple comparison test.

      Clinical, Psychological Characteristics and Quality of Life (N=131)

      SD=Standard deviation; RA=Rheumatoid arthritis; ADL=Activities of daily living; KHAQ=Korean health assessment questionnaire; DAS28-ESR= Disease activity score 28-erythrocyte sedimentation rate; VAS=Visual analogue scale; QOL=Quality of life; CES-D=The center for epidemiologic studies-depression scale; SF-36=The medical outcomes study short form 36 health survey.

      Correlation Coefficients of Study Variables with Physical and Mental QOL (N=131)

      RA=Rheumatoid arthritis; QOL=Quality of life; ADL=Activities of daily living.

      Factors Predicting Physical QOL (N=131)

      a=Dummy coded (married=1, single=0); b=Dummy coded (employed=1, unemployed=0); c=Dummy coded (Catholic or Protestant=1, none or Buddhist=0); VAS=Visual analogue scale; QOL=Quality of life; ADL=Activities of daily living; DAS28-ESR=Disease Activity Score 28-Erythrocyte Sedimentation Rate; KHAQ=Korean health assessment questionnaire; RA=Rheumatoid arthritis; CES-D=The Center for Epidemiologic Studies-Depression Scale.

      Factors Predicting Mental QOL (N=131)

      a=dummy coded (married=1, single=0); b=dummy coded (Catholic or Protestant=1, none or Buddhist=0); c=dummy coded (employed=1, unemployed=0); VAS=Visual analogue scale; QOL=Quality of life; ADL=Activities of daily living; DAS28-ESR=Disease Activity Score 28-Erythrocyte Sedimentation Rate; KHAQ=Korean health assessment questionnaire; RA=Rheumatoid arthritis; CES-D=The Center for Epidemiologic Studies-Depression Scale.
      Table 1 Health related Quality of Life by Sociodemographic Variables (N=131)

      QOL=Quality of life.

      *p<.05; **p<.01; †The same letters indicate nonsignificant difference between groups based on Tukey's multiple comparison test.

      Table 2 Clinical, Psychological Characteristics and Quality of Life (N=131)

      SD=Standard deviation; RA=Rheumatoid arthritis; ADL=Activities of daily living; KHAQ=Korean health assessment questionnaire; DAS28-ESR= Disease activity score 28-erythrocyte sedimentation rate; VAS=Visual analogue scale; QOL=Quality of life; CES-D=The center for epidemiologic studies-depression scale; SF-36=The medical outcomes study short form 36 health survey.

      Table 3 Correlation Coefficients of Study Variables with Physical and Mental QOL (N=131)

      RA=Rheumatoid arthritis; QOL=Quality of life; ADL=Activities of daily living.

      Table 4 Factors Predicting Physical QOL (N=131)

      a=Dummy coded (married=1, single=0); b=Dummy coded (employed=1, unemployed=0); c=Dummy coded (Catholic or Protestant=1, none or Buddhist=0); VAS=Visual analogue scale; QOL=Quality of life; ADL=Activities of daily living; DAS28-ESR=Disease Activity Score 28-Erythrocyte Sedimentation Rate; KHAQ=Korean health assessment questionnaire; RA=Rheumatoid arthritis; CES-D=The Center for Epidemiologic Studies-Depression Scale.

      Table 5 Factors Predicting Mental QOL (N=131)

      a=dummy coded (married=1, single=0); b=dummy coded (Catholic or Protestant=1, none or Buddhist=0); c=dummy coded (employed=1, unemployed=0); VAS=Visual analogue scale; QOL=Quality of life; ADL=Activities of daily living; DAS28-ESR=Disease Activity Score 28-Erythrocyte Sedimentation Rate; KHAQ=Korean health assessment questionnaire; RA=Rheumatoid arthritis; CES-D=The Center for Epidemiologic Studies-Depression Scale.

      Table 1

      Table 2

      Table 3

      Table 4

      Table 5

      J Korean Acad Nurs : Journal of Korean Academy of Nursing
      © Korean Society of Nursing Science.
      Close layer
      TOP