Seung-Ae Park; Jong-Kyung Kim

doi:10.4040/jkan.2011.41.2.191

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Original Article
Estrogen Attenuates the Pressor Response Mediated by the Group III Mechanoreflex: Seung-Ae Park, Jong-Kyung Kim; Journal of Korean Academy of Nursing 2011;41(2):191-196.
DOI: https://doi.org/10.4040/jkan.2011.41.2.191
Published online: April 30, 2011

¹Doctoral Student, Graduate School of Physical Education, Kyung Hee University, Yongin, Korea.

²Assistant Professor, Graduate School of Physical Education, Kyung Hee University, Yongin, Korea.

Address reprint requests to: Kim, Jong-Kyung. Graduate School of Physical Education, Kyung Hee University, 1 Seocheon-dong, Giheung-gu, Yongin 446-701, Korea. Tel: +82-31-201-2778, Fax: +82-31-201-3743, kyung19692002@khu.ac.kr

• Received: September 4, 2010 • Accepted: April 15, 2011

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Abstract
NOTES
NOTES
REFERENCES

Abstract

Purpose
We investigated the effects of group III mechanoreceptors to cardiovascular responses in both pre-menopausal woman and post-menopausal woman during passive ankle dorsiflexion (PAD).
Methods
Twenty healthy volunteers (10 post-menopausal women and 10 pre-menopausal women) were recruited for this study. Stroke volume (SV), heart rate (HR), cardiac output (CO), and total vascular conductances (TVC) were measured continuously throughout the experiment. To stimulate the group III mechanoreceptors, PAD was performed for one minute.
Results
The results showed that mean arterial pressure (MAP) mediated by the mechanoreflex activation was significantly increased in both groups. However, this pressor response was significantly higher in post-menopausal women. This reflex significantly increased both SV and CO in pre-menopausal women, while there were no differences in post-menopausal women. There was no difference in HR in either group. The mechanoreflex significantly decreased TVC in post-menopausal woman, while there was no difference in pre-menopausal woman.
Conclusion
The results indicate that the excessive pressor response mediated by the mechanoreflex occurs due to overactivity of group III mechanorecptors and the mechanism is produced mainly via peripheral vasoconstriction in post-menopausal women.
Keywords: Estrogen; Post-menopausal woman; Exercise pressor reflex; Group III mechanoreceptors; Cardiac output

This study is a thesis of master of science.

This work was supported by a grant from Kyung Hee University in 2006 (KHU-20061278).

REFERENCES

1. Craig AD, Mense S. The distribution of afferent fibers from the gastrocnemius-soleus muscle in the dorsal horn of the cat as revealed by the transport of horseradish peroxidase. Neuroscience Letters. 1983;41:233–238.Article PubMed
2. Cui J, Blaha C, Moradkhan R, Gray KS, Sinoway LI. Muscle sympathetic nerve activity responses to dynamic passive stretch in humans. The Journal of Physiology. 2006;576:625–634.Article PubMed PMC
3. Ettinger S, Silber DH, Collins BG, Gray KS, Sutliff G, Whisler SK, et al. Influences of gender on sympathetic nerve responses to static exercise. Journal of Applied Physiology. 1996;80:245–251.Article PubMed
4. Ettinger SM, Silber DH, Gray KS, Smith MB, Yang QX, Kunselman AR, et al. Effects of the ovarian cycle on sympathetic neural outflow during static exercise. Journal of Applied Physiology. 1998;85:2075–2081.Article PubMed
5. Gladwell VF, Coote JH. Heart rate at the onset of muscle contraction and during passive muscle stretch in humans: A role for mechanoreceptors. Journal of Physiology. 2002;540:1095–1102.Article PubMed PMC
6. Hayes SG, Kaufman MP. Gadolinium attenuates exercise pre-ssor reflex in cats. American Journal of Physiology. Heart and Circulatory Physiology. 2001;280:H2153–H2161.Article PubMed
7. Hayes SG, Kindig AE, Kaufman MP. Comparison between the effect of static contraction and tendon stretch on the discharge of grup III and IV muscle afferents. Journal of Applied Physiology. 2005;99:1891–1896.Article PubMed
8. Hayes SG, Moya del Pino NB, Kaufman MP. Estrogen attenuates the cardiovascular and ventilatory responses to central command in cats. Journal of Applied Physiology. 2002;92:1635–1641.Article PubMed
9. Innes KE, Selfe TK, Taylor AG. Menopause, the metabolic syndrome, and mind-body therapies. Menopause. 2008;15:1005–1013.Article PubMed PMC
10. Kim JK, Augustyniak RA, Sala-Mercado JA, Hammond RL, Ansorge EJ, Rossi NF, et al. Heart failure alters the strength and mechanisms of arterial baroreflex pressor responses during dynamic exercise. American Journal of Physiology. Heart and Circulatory Physiology. 2004;287:H1682–H1688.Article PubMed
11. Kim JK, Hayes SG, Kindig AE, Kaufman MP. Thin-fiber mechanoreceptors reflexly increase renal sympathetic nerve activity during static contraction. American Journal of Physiology. Heart and Circulatory Physiology. 2007;292:H866–H873.Article PubMed
12. Koba S, Xing J, Sinoway LL, Li J. Differential sympathetic outflow elicited by active muscle in rats. American Journal of Physiology. Heart and Circulatory Physiology. 2007;293:H2335–H2343.Article PubMed
13. McCloskey DI, Mitchell JH. Reflex cardiovascular and respiratory responses originating in exercising muscle. Journal of Physiology. 1972;224:173–186.Article PubMed PMC
14. Pines A, Fisman EZ, Shapira I, Drory Y, Weiss A, Eckstein N, et al. Exercise echocardiography in post-menopausal hormone users with mild systemic hypertension. American Journal of Cardiology. 1996;78:1385–1389.Article PubMed
15. Rosano GMC, Sarrel PM, Poole-Wilson PA, Collins P. Beneficial effect of estrogen on exercise-induced myocardial ischemia in women with coronary artery disease. Lancet. 1993;342:133–136.PubMed
16. Schmitt PM, Kaufman MP. Estrogen attenuates the exercise pressor reflex in female cats. Journal of Applied Physiology. 2003;95:1418–1424.Article PubMed
17. Schmitt PM, Kaufman MP. Estrogens attenuating effect on the exercise pressor reflex is more opioid dependent in gonadally intact than in ovariectomized female cats. Journal of Applied Physiology. 2005;98:633–639.Article PubMed
18. Sinoway LI, Li J. A perspective on the muscle reflex: implications for congestive heart failure. Journal of Applied Physiology. 2005;99:5–22.Article PubMed
19. Smith SA, Mitchell JH, Garry MG. The mammalian exercise pressor reflex in health and disease. Experimental Physiology. 2006;91:89–102.Article PubMed PDF
20. Smith SA, Williams MA, Leal AK, Mitchell JH, Garry MG. Exercise pressor reflex function is altered in spontaneously hypertensive rats. The Journal of Physiology. 2006;577:1009–1020.Article PubMed PMC
21. Tsuchimochi H, Matsukawa K, Komine H, Murata J. Direct measurement of cardiac sympathetic efferent nerve activity during dynamic exercise. American Journal of Physiology. Heart and Circulatory Physiology. 2002;283:H1896–H1906.Article PubMed
22. Van Groningen LF, Adiyaman A, Elving L, Thien T, Lenders JW, Deinum J. Which physiological mechanism is responsible for the increase in blood pressure during leg crossing? Journal of Hypertension. 2008;26:433–437.Article PubMed

Figure 1

Experimental foot ankle dorsiflexion

Figure 2

Cardiovascular responses mediated by the mechanorefelx during foot ankle dorsiflexion.

Values are mean±standard error. PMW=Premenopausal woman; PTW=Postmenopausal woman; Black Bar: baseline; Gray Bar: mechanoreflex activation. ^*Significantly different from baseline value, p<.05; #Significantly different from PMW, p<.05; MAP=mean arterial pressure; HR=heart rate; SV=stroke volume; CO cardiac output; TVC=total vascular conductances.

Table 1

Physical Characteristics of Participants

Values are mean±standard error.

^*p<.05 vs. PMW.

PMW=premenopausal woman; PTW=postmenopausal woman; SBP=systolic blood pressure; DBP=diastolic blood pressure.

Figure & Data

REFERENCES

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Estrogen Attenuates the Pressor Response Mediated by the Group III Mechanoreflex

J Korean Acad Nurs. 2011;41(2):191-196. Published online April 30, 2011

DOI: https://doi.org/10.4040/jkan.2011.41.2.191

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Figure

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Estrogen Attenuates the Pressor Response Mediated by the Group III Mechanoreflex

Figure 1 Experimental foot ankle dorsiflexion

Figure 2 Cardiovascular responses mediated by the mechanorefelx during foot ankle dorsiflexion. Values are mean±standard error. PMW=Premenopausal woman; PTW=Postmenopausal woman; Black Bar: baseline; Gray Bar: mechanoreflex activation. *Significantly different from baseline value, p<.05; #Significantly different from PMW, p<.05; MAP=mean arterial pressure; HR=heart rate; SV=stroke volume; CO cardiac output; TVC=total vascular conductances.

Figure 1

Figure 2

Estrogen Attenuates the Pressor Response Mediated by the Group III Mechanoreflex

Table 1

Physical Characteristics of Participants

Values are mean±standard error.

^*p<.05 vs. PMW.

PMW=premenopausal woman; PTW=postmenopausal woman; SBP=systolic blood pressure; DBP=diastolic blood pressure.

Table 1 Physical Characteristics of Participants

Values are mean±standard error.

^*p<.05 vs. PMW.

PMW=premenopausal woman; PTW=postmenopausal woman; SBP=systolic blood pressure; DBP=diastolic blood pressure.