Dal Sook Kim; Myung Hee Jun

doi:10.4040/jkan.2008.38.2.321

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Original Article
Body Fat Percentage and Natural Killer Cell Activity of Breast and Rectal Cancer Patients after Diagnosis but before Treatment: Dal Sook Kim, Myung Hee Jun; Journal of Korean Academy of Nursing 2008;38(2):321-331.
DOI: https://doi.org/10.4040/jkan.2008.38.2.321
Published online: April 30, 2008

¹Professor, Department of Nursing, Chungnam National University, Daejeon, Korea.

²Professor, Department of Nursing, Daejeon University, Daejeon, Korea.

Address reprint requests to: Kim, Dal Sook. Department of Nursing, Chungnam National University, 6 Munhwa-dong, Jung-gu, Daejeon 301-747, Korea. Tel: 82-42-580-8327, Fax: 82-42-584-8915, dskim@cnu.ac.kr

• Received: November 20, 2008 • Accepted: April 3, 2008

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Abstract
NOTES
REFERENCES

Abstract

Purpose
To examine the relationship between body fat percentage (BFP) and N-K cell activity (NKCA) in Korean breast and rectal cancer patients just after diagnosis.
Methods
With 35 subjects enrolled between November 2002 and May 2003, Bioelectrical Impedance Analysis was used to estimate BFP. FACS Analysis was used to measure N-K cell activity. The relationships between BFP and NKCA were identified by using curve estimation, simple regression, and multiple regression.
Results
The mean BFPs of the subjects and all the sub-groups were higher than acceptable BFPs. Both the mean NKCAs of male and female subjects were lower than that of healthy women. NKCA was explained by BFP with a 14.9% variance in the total subjects (p<.05). There were significant negative relationships between BFP and NKCA after controlling age, type of cancer, and stage of cancer while no significant relationship was found after controlling for gender. The relationships between BFP and NKCA in the sub-groups of female, breast cancer, and stage I, and II were significant. The relationships between male, rectal cancer, and the stage III, and VI sub-groups were not identified, but they revealed a mild to moderate steep in curve estimation.
Conclusion
Weight reduction could prevent the risk and advancement of breast and rectal cancer in Koreans.
Keywords: Body fat; Natural killer cell; Breast cancer; Rectal cancer; Weight reduction

This work was supported by grant No R04-2002-000-00077-0 from the Basic Research Program of the Korea Science & Engineering Foundation.

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Figure 1

Viewing the relationship between body fat (%) and N-K cell activity (% gated) with linear and power curve on curve estimation (N=35).

Table 1

Descriptions of Natural Killer Cell Activity and Body Fat Percentage

^*comprising 8 stage III, IV rectal cancer patients; ^†comprising 17 stage I, II breast cancer patients, 2 stage III, IV breast cancer patients, 5 stage I, II rectal cancer patients, and 3 stage III, IV recral cancer patients.

Table 2

Relationships between Total Body Fat (%) and N-K Cell Activity (% gated) in Linear Regression Models

^*for the total subjects (N=35); ^†for the female subjects (N=27); ^‡for the breast cancer patients (N=19); ^§for the subjects at the stage I, II (N=22).

Table 3

Relationships between Body Fat (%) and N-K Cell Activity (% gated) in Age, Gender, Type of Cancer, and the Stage at Diagnosis Controlled (N=35)

Figure & Data

REFERENCES

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Body Fat Percentage and Natural Killer Cell Activity of Breast and Rectal Cancer Patients after Diagnosis but before Treatment

Journal of Korean Academy of Nursing. 2008;38(2):321-331. Published online April 30, 2008

DOI: https://doi.org/10.4040/jkan.2008.38.2.321

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Figure

We recommend

Body Fat Percentage and Natural Killer Cell Activity of Breast and Rectal Cancer Patients after Diagnosis but before Treatment

Figure 1 Viewing the relationship between body fat (%) and N-K cell activity (% gated) with linear and power curve on curve estimation (N=35).

Figure 1

Body Fat Percentage and Natural Killer Cell Activity of Breast and Rectal Cancer Patients after Diagnosis but before Treatment

Table 1

Descriptions of Natural Killer Cell Activity and Body Fat Percentage

Table 2

Relationships between Total Body Fat (%) and N-K Cell Activity (% gated) in Linear Regression Models

^*for the total subjects (N=35); ^†for the female subjects (N=27); ^‡for the breast cancer patients (N=19); ^§for the subjects at the stage I, II (N=22).

Table 3

Relationships between Body Fat (%) and N-K Cell Activity (% gated) in Age, Gender, Type of Cancer, and the Stage at Diagnosis Controlled (N=35)

Table 1 Descriptions of Natural Killer Cell Activity and Body Fat Percentage

Table 2 Relationships between Total Body Fat (%) and N-K Cell Activity (% gated) in Linear Regression Models

^*for the total subjects (N=35); ^†for the female subjects (N=27); ^‡for the breast cancer patients (N=19); ^§for the subjects at the stage I, II (N=22).

Table 3 Relationships between Body Fat (%) and N-K Cell Activity (% gated) in Age, Gender, Type of Cancer, and the Stage at Diagnosis Controlled (N=35)