Journal of Korean Academy of Nursing

Review Articles

Effectiveness of Non-Pharmacologic Interventions in Chemotherapy Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis: Pok-Ja Oh, You Lim Kim; J Korean Acad Nurs 2018;48(2):123-142. Published online January 15, 2018; DOI: https://doi.org/10.4040/jkan.2018.48.2.123

Abstract Purpose

This study was conducted to evaluate the effectiveness of non-pharmacologic interventions in chemotherapy-induced peripheral neuropathy (CIPN).

Methods

PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL, and several Korean databases (Until August 2017) were searched. The main search strategy combined terms for peripheral neuropathy and presence of neoplasms. The risk of bias was assessed using the Cochrane's Risk of Bias tool for randomized studies and the Risk of Bias Assessment tool for non-randomized studies. To estimate the effect size, a meta-analysis of the studies was performed using the Rev Man 5.3 program of the Cochrane Library random-effects models were used in the analyses.

Results

Twenty-two studies with a total of 954 participants met the inclusion criteria. Of the 22 studies, 12 were used to estimate the effect size of the non-pharmacologic interventions. The non-pharmacologic interventions used in patients with CIPN were exercise, acupuncture, massage, and foot bath. The acupuncture significantly reduced CIPN symptoms and signs (d=-0.71) and CIPN pain (d=-0.73) (p<.001). Massage and foot bath were also effective in reducing CIPN symptoms (d=-0.68; 95% CI=-1.05, -0.30; p<.001; I²=19%).Exercis-es were effective in improving muscle strength and endurance(d=-0.55) and quality of life (d=-2.96), but they were not significantly effective in improving CIPN.

Conclusion

Although these results provide little evidence of the effectiveness of acupuncture, massage, and foot bath in the treatment of CIPN, they suggest that these interventions can reduce CIPN symptoms in patients with cancer. However, the findings of this study should be interpreted with caution as there is a relative lack of data in this field, and additional well-designed studies are needed. PROSPERO registration: CRD42017076278.

Citations

Citations to this article as recorded by

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Effects of acupuncture-related intervention on chemotherapy-induced peripheral neuropathy and quality of life: An umbrella review
Mei-Ling Yeh, Chin-Che Hsu, Matthew Lin, Chuan-Ju Lin, Jaung-Geng Lin
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Acupuncture-related interventions improve chemotherapy-induced peripheral neuropathy: A systematic review and network meta-analysis
Mei-Ling Yeh, Ru-Wen Liao, Pin-Hsuan Yeh, Chuan-Ju Lin, Yu-Jen Wang
BMC Complementary Medicine and Therapies.2024;[Epub] CrossRef
Effect of Exercise Intervention on Chemotherapy-Induced Peripheral Neuropathy Symptoms in Cancer Patients: A Meta-analysis
Nan Wu, Hongshi Cao, Shiyuan Du, Yulu Chen, Xinxin Wang, Jiong Li, Xin Peng
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Properties of the Measures to Assess Oxaliplatin-induced Peripheral Neuropathy: A Literature Review: Sang Hui Chu, Yoon Ju Lee, Young Joo Lee, Charles S. Cleeland; J Korean Acad Nurs 2015;45(6):783-801. Published online December 31, 2015; DOI: https://doi.org/10.4040/jkan.2015.45.6.783

Abstract PDF

Purpose

The purpose of this study is to provide a comprehensive overview of the various measures available for assessment of oxaliplatin-induced peripheral neuropathy (OXLIPN) and to evaluate the measurement properties of each assessment tool.

Methods

A systematic review was conducted to identify existing measures for OXLIPN found in the databases of PubMed, Cochrane Library, Embase, RISS and KoreaMed. The quality of the 24 identified tools was evaluated based on their properties of measurement including content validity, internal consistency, criterion validity, construct validity, reproducibility, responsiveness, floor-ceiling effects and interpretability.

Results

Ten (41.7%) of the 24 tools were identified as specific measures for assessing OXLIPN and the most popular type of measures were clinical grading systems by clinicians (58.3%) and only 29.2% of measures were identified as patient reported outcomes. The most frequently used tool was National Cancer Institute-Common Toxicity Criteria (NCI-CTC), but the validity of NCI-CTC has not been reported appropriately. Overall, the Neuropathic Pain Symptom Inventory (NPSI) received the best psychometric scores, and the Chemotherapy-induced Peripheral Neuropathy Assessment Tool (CIPNAT) and Functional Assessment of Cancer Therapy/Gynaecologic Oncology Group-neurotoxicity-12 (FACT/GOG-Ntx-12) followed NPSI.

Conclusion

To select appropriate measure, evidences should be accumulated through the clinical use of tools. Therefore, practitioner and researchers are urged to report relevant statistics required for the validation of the currently used measures for assessment of OXLIPN.

Citations

Citations to this article as recorded by

Psychometric Properties of the Korean Version of the Chemotherapy-Induced Peripheral Neuropathy Assessment Tool
Mi Sook Jung, Mijung Kim, Kyeongin Cha, Xirong Cui, Ji Wan Lee
Research and Theory for Nursing Practice.2022; 36(4): 422. CrossRef
A Systematic Review of Measurement Properties of Spirituality related Assessment Tools Published in Korean Journals
Il-Sun Ko, Jin Sook Kim, Soyoung Choi
Journal of Korean Academy of Fundamentals of Nursing.2021; 28(1): 133. CrossRef
The Efficacy of Acupuncture in Chemotherapy-Induced Peripheral Neuropathy: Systematic Review and Meta-Analysis
Tsai-Ju Chien, Chia-Yu Liu, Ching-Ju Fang, Chun-Yu Kuo
Integrative Cancer Therapies.2019;[Epub] CrossRef
The psychometric properties of the Turkish version of the Chemotherapy-Induced Peripheral Neuropathy Assessment Tool (CIPNAT)
Sevinç Kutlutürkan, Elif Sözeri Öztürk, Fatma Arıkan, Burcu Bayrak Kahraman, Keziban Özcan, Mürvet Artuk Uçar
European Journal of Oncology Nursing.2017; 31: 84. CrossRef

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