Antineoplastic agents may exhibit effects not only in patients therapeutically exposed, but also in health workers who prepare and administer these drugs. This study was done to clarify whether nurses who handle anticancer drugs show signs of drug absorption. The experimental group was 14 nurses handling anticancer drugs at three medical wards of a hospital in J city ; the control group was 12 psychiatric nurses at the same hospital. The test materials were the nurses' 24hr urine specimens, which were concentrated by XAD-2column chromatograpy. Tester strains were TA98(+/-S9mix), TA100(+/-S9mix), TA135(+/-S9mix)and TA1537(+/-S9mix) ; the salmonella mammalian microsomal test(Ames test) was used for the urinary mutagenicity assay. The results are summarized as follow : 1. In qualitative analysis of the results, both experimental group and control group showed 15.4% urine toxicity. 2. The experimental group revealed significantly higher urinary mutagenicity both in the activation method test and non-activation method test of the tester strains TA98, TA100 and TA1535. In the case of TA1537, the two groups showed no difference in the non-activation method test, but the activation method revealed a difference. 3. In urinary mutagenicity of the experimental group by ward career, there was a significant difference between the group with more than 20 months experience and the group with less than 20 months on the tester strains TA98, TA100, and two groups by the tester strain TA1537. No Significant difference was found between two groups by the tester strain TA1535.
This study was done to identify some natural meaning through the dosage experience of psychoactive drugs in women patients with schizophrenia.
The Hermeneutic phenomenology written by van Manen was used. The period for data collection was from November 2009 to January 2010. This study took place in mental health hospitals and mental health centers in two cities in North Jeolla Province. Nine patients with schizophrenia participated. Data collection was done through individual in-depth interview.
The seven natural subjects demonstrated by participants from this study were 'Pills forcibly taken like veiled threats', 'A terrible side effect, a side effect rooted slowly', 'Shame which cannot be hidden as a woman', 'A bad medicine took away from motherhood', 'The fate of a wife who can't be equal', 'A struggle for the complete recovery without promise', and 'Participants want the future without medicine'.
The results of this study indicate that the urgent need to develop a safe and believable psychoactive drug for woman patients considering the time of menstruation, pregnancy, childbirth, and child raising.
This study was done to understand elderly women within a community who have used lots of drugs.
Data was collected through in-depth interviews with four elderly women from April 2001 to February 2002. Data was analyzed by Giorgi's phenomenological method(2000).
The components in common with drug usage of elderly women were as follows: ‘Awareness of the limitation of physical strength and uncertainty of life’, ‘Dread of a crisis situation occurring’, ‘Attachment and dependency on drugs’, ‘Expectation of a comfortable life and death’, ‘Prevention of family burden’, and ‘Pursuit of psychological comfort’. The general structure of experiences was as follows: causal factors were ‘Awareness of uncertainty and limitation’, ‘dread of a crisis situation occurring’ the results factor was ‘Attachment and dependency on drugs’ and the facilitating factors were ‘Expectation of a comfortable life and death’, ‘Prevention of family burden’, and ‘Pursuit of psychological comfort’. The causal relation was cyclic. This structure showed a realistic adaptation pattern.
This study contributed to provide fundamental data for nursing interventions for health promotion and promoting quality of life in elderly women by increasing understanding of the experiences of drugs use.