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Effects of Blending Oil of Lavender and Thyme on Oxidative Stress, Immunity, and Skin Condition in Atopic Dermatitis Induced Mice
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Young Mi Seo, Seok Hee Jeong
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J Korean Acad Nurs 2015;45(3):367-377. Published online June 30, 2015
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DOI: https://doi.org/10.4040/jkan.2015.45.3.367
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Abstract
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Purpose
The purpose of this study was to evaluate the effects of essential oil on oxidative stress, immunity, and skin condition in atopic dermatitis (AD) induced mice.
Methods
This study was a 3×3 factorial design. Factors were oil type (Lavender, Thyme, and 2:1 mixture of lavender and thyme oil [blending oil]) and treatment period (0 day, 7 days, and 21 days). The samples were 45 mice with AD and randomly assigned to nine groups of five mice per group. The dependent variables such as superoxide radical, IgE, degranulated mast cells, and epidermal thickness were measured. Data were collected from February to April in 2014. Descriptive statistics, One-way ANOVA, Two-way ANOVA, and Tukey's HSD test were performed using the SPSS WIN 20.0 program.
Results
Dependent variables were not statistically significantly different by the three oil types (p>.05). Essential oils such as lavender, thyme, and blending oil were all effective in reducing AD symptoms and especially 2:1 blending oil were most effective. There were statistically significant differences by the three treatment periods in all dependent variables (p<.001). There were statistically significant interactions between oil types and treatment periods in all dependent variables (p<.01). For decreasing superoxide radical, degranulated mast cells, and epidermal thickness, 2:1 mixed oil should be applied for at least 21 days. Otherwise to reduce IgE, 2:1 mixed oil should be used for at least 7 days.
Conclusion
These findings provide bases for developing effective interventions for AD patients to manage their AD symptoms.
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Citations
Citations to this article as recorded by 
- Essential oils in cosmetics: Antioxidant properties and advancements through nanoformulations
Bongunuri Harsha Vardhan Reddy, Sha Mohammad Sameer Hussain, Mohammad Shahil Hussain, Rajpurohit Narendra Kumar, Jeena Gupta Pharmacological Research - Natural Products.2025; 6: 100192. CrossRef - Harnessing the health perks of underrated spices in bakery products- A review
Hassan Mehmood Sipra, Asad Ali, Qamar Abbas Syed, Muhammad Irfan, Syed Ali Hassan Food Chemistry Advances.2024; 5: 100790. CrossRef - A comparative study on a biodegradable hyaluronic acid microneedle patch with a needleless patch for dry skin in atopic dermatitis: a single-blinded, split-body, randomized controlled trial
Ji-Hoon Song, Eun Jin An, Chang Yub Sung, Do Hyeon Jeong, Gihyun Lee, Soo-Yeon Park Archives of Dermatological Research.2022; 315(3): 569. CrossRef - Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance
Abdul Q. Khan, Maha Victor Agha, Khalid Sultan A.M. Sheikhan, Shahd M. Younis, Maha Al Tamimi, Majid Alam, Aamir Ahmad, Shahab Uddin, Joerg Buddenkotte, Martin Steinhoff Biomedicine & Pharmacotherapy.2022; 154: 113601. CrossRef - A randomized controlled trial of combination of peppermint, lavender, and turmeric oil for antipruritic agent in pregnant women
Fransisca Retno Asih, Farid Husin, Oki Suwarsa, Irda Fidrianny, Dany Hilmanto Medical Journal of Indonesia.2021; 30(1): 39. CrossRef - Effects of Evening Primrose Oil and Evening Primrose–rosemary Mixed Oil on Atopic Dermatitis-induced Animal Model
Seon Ju Kim, Shin Hee Park Asian Journal of Beauty and Cosmetology.2017; 15(4): 399. CrossRef - Topical Application of Cudrania tricuspidata Stem Extract Inhibits Atopic Dermatitis-Like Skin Lesions in an NC/Nga Mouse Model: An Experimental Animal Study
Yoo-Sin Park, Shin-Hee Kim, Sang-Yeon Kim, Gae-Myoung Koh, Ju-Hwan Suh, Ju-Seop Kang Pharmacology & Pharmacy.2016; 07(08): 358. CrossRef
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Effects of Education on Knowledge and Practice of Caregivers of the Stroke Patient
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Jae Sun Choi, Young Mi Seo, In Soo Kwon
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Journal of Korean Academy of Nursing 2006;36(7):1175-1182. Published online December 31, 2006
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DOI: https://doi.org/10.4040/jkan.2006.36.7.1175
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Abstract
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Purpose
This study was conducted to evaluate the effects of stroke patient care education on the knowledge and practice of caregivers of stroke patients.
Method
Data was collected from December 15, 2004 to March 30, 2005. The research design was a non-equivalent control group non-synchronized design. The subjects were forty primary caregivers of stroke patients who were hospitalized in a neurology unit of a university hospital. Forty caregivers, twenty in the experimental group and twenty in the control group were assigned. The experimental group participated 2 times in an education class given by the researcher. Data analysis included -test, and t-test using the SPSS program.
Result
Knowledge(t=5..87, p=o.oo) and practice(t=5.53, p=0.00) of the experimental group were significantly different from the control group.
Conclusion
The stroke patient care education developed in this studyshows a significant promotion of knowledge and practice of caregivers. Thus this program can be recommanded as an intervention model for stroke patients and caregivers.
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Citations
Citations to this article as recorded by 
- Comprehensive Stroke Education Program (CSEP) on Knowledge and Quality of Life among Patients with Stroke and Burden among Caregivers
Baminidevi Nagarajan Nursing and Health Care.2019; : 71. CrossRef - Effects of a Self-help Management Program at Public Health Centers on Self-efficacy, Self-esteem, Knowledge of Stroke, and Family Supports in Stroke Patients
Koung-Oh Chang Journal of Korean Academy of Community Health Nursing.2013; 24(4): 388. CrossRef - The Effects of Self-help Management Program on Knowledge about Stroke, Self-efficacy and Self-esteem in People with Stroke
Koung-Oh Chang, Jung Yeon Park Journal of muscle and joint health.2013; 20(1): 1. CrossRef - The Effects of an Environmental Education with Newspaper in Education (NIE) on the Environmental Concern and Practice
Ki-Wol Sung Journal of Korean Academy of Nursing.2008; 38(6): 891. CrossRef
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The Effect of Education Program on Primiparas' knowledge, confidence and Accuracy of Behavior in Newborn Care
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Young Mi Seo
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Journal of Korean Academy of Nursing 1998;28(4):1060-1074. Published online March 29, 2017
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DOI: https://doi.org/10.4040/jkan.1998.28.4.1060
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Abstract
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This study was to find whether the educational program contributed to the increase of knowledge, confidence, and accuracy of behavior in newborn care of the primiparas. The educational program consists of individual lectures, demonstrations, discussion, and practice of newborn care. Also two telephone counseling with the subjects after they are discharged from hospital. This study is a quasi-experimental design using non-equivalent control group pretest-posttest design. Data collection was done from July 21 to Oct 4 in 1997. the subjects were selected from 2 general hospitals and 1 university hospital in C city. Subjects were 44 primiparas(control group 22, experimental group 22). they were tested on knowledge, confidence, and accuracy of behavior in newborn care. A pretest was done 2-3 years after vaginal delivery(5-6 days after c-sec delivery). A posttest was done 21-28 day(vaginal delivary, c-sec delivary) after delivery. The instruments used for this study were knowledge scale about newborn care developed by the researcher, Pharis' confidence scale modified by the researcher and accuracy of behavior scale developed by the researcher. Primiparas' knowledge and confidence was tested by questionnaire and Primiparas' accuracy of behavior was tested by structured observational method. Analysis of data was done by using of x2-test, t-test, paired t-test. The results of this study are summarized as follows; 1) Knowledge of the experimental group was significant higher than the control group(t=-4.94, P=.000). 2) Confidence of the experimental group was significant higher than the control group(t=-.262, P=.012). 3) Accuracy of behavior of the experimental group was significant higher than the control group(t=-.969, P=.000). In conclusion, the newborn care education along with intensive telephone counseling shows a significant promotion of newborn care in primiparas. Thus this program can be recommended as an intervention model for the newborn and primiparas.
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Citations
Citations to this article as recorded by 
- Effects of the Newborn Parenting Program for Marriage Immigrant Primiparas on their Parenting Stress and Mothers’ Role Confidence
Jinhee Lee, Sangeun Oh Korean Journal of Stress Research.2016; 24(3): 220. CrossRef - Participation in Prenatal Education, Knowledge and Attitude related to Delivery, Postpartum Care, Newborn Care in Nulliparous Women
Mi-Young Kim, Gwang-Suk Kim, Sue Kim, Hye-Jung Lee Korean Journal of Women Health Nursing.2016; 22(3): 139. CrossRef - A Study of First-time Fathers on Their Knowledge and Confidence in Newborn
NamSuk Kim Journal of Digital Convergence.2016; 14(8): 537. CrossRef - Development of an Infants' Sleep Health Program Using a Video for SIDS Prevention Education and Measurement of the Program's Effects.
Sook Jang, Il Ok Kim Child Health Nursing Research.2015; 21(1): 11. CrossRef - Effects of Newborn Care Education for First-time Fathers on Their Knowledge and Confidence in Newborn Care at Postpartum One Month
Hye-Sun An, Kyung-Sook Bang Journal of Korean Academy of Nursing.2014; 44(4): 428. CrossRef - Effects of Maternal Role Practice Education on Becoming a Mother
Hyun-Ju Chea, Sue Kim Korean Journal of Women Health Nursing.2011; 17(1): 52. CrossRef - Effects of Early Contact on Maternal Infant Attachment
Mi-Hae Sung, Myung-Ran Choi, Ok-Bong Um Korean Journal of Women Health Nursing.2010; 16(2): 177. CrossRef
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