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Effects of Isometric Contraction Training by Electrostimulation on Type I and II Hindlimb Muscles in Cerebral Ischemia Model Rats
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Yoon Kyong Lee, Myoung Ae Choe, Gyeong Ju An
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Journal of Korean Academy of Nursing 2006;36(7):1232-1241. Published online December 31, 2006
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DOI: https://doi.org/10.4040/jkan.2006.36.7.1232
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 Abstract
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Purpose
The purpose of this study was to examine the effects of cerebral ischemia on Type I(soleus) and Type II(plantaris, gastrocnemius) muscles, and to determine the effects of isometric contraction training by electrostimulation on Type I andII muscles in cerebral ischemia model rats.
Method
Twenty-five male Sprague-Dawley rats were randomly divided into four groups: ST(stroke), STES(stroke+electrostimulation), SH(sham) and SHES (sham+electrostimulation). The ST and STES groups received a transient right middle cerebral artery occlusion operation. The SH and SHES groups received a sham operation. The STES and SHES groups had daily isometric contraction training by electrostimulation(100Hz, 45mA, 7.5V) on hindlimb muscles for 7days.
Result
Plantaris and gastrocenmius muscle weight, myofibrillar protein contents of soleus and gastrocnemius, and the muscle fiber cross-sectional area of gastrocnemius in the ST group significantly decreased compared with the SH group. Soleus, plantaris, gastrocnemius muscle weight, myofibrillar protein contents of soleus and gastrocnemius, and the Type I muscle fiber cross-sectional area of soleus and the Type II muscle fiber cross-sectional area of gastrocnemius in the STES group significantly increased compared with the ST group.
Conclusion
Hindlimb muscle atrophy occurs after acute stroke and isometric contraction training by electrostimulation during early stages of a stroke attenuates muscle atrophy of Type I and Type II muscles.
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Citations
Citations to this article as recorded by  - Use of Animals for Nursing Research in Korea
Hae Young Yoo
Journal of Korean Biological Nursing Science.2015; 17(4): 324. CrossRef - Hindlimb Muscle Atrophy Occurs From Short-Term Undernutrition in Rats
Jee Yoon Kim
Biological Research For Nursing.2013; 15(4): 459. CrossRef
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Effect of Regular Exercise during Recovery Period Following Steroid Treatment on the Atrophied Type II Muscles Induced by Steroid in Young Rats
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Myoung Ae Choe, Gi Soo Shin, Gyeong Ju An, Jung An Choi, Yoon Kyong Lee
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Journal of Korean Academy of Nursing 2002;32(4):550-559. Published online March 29, 2017
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DOI: https://doi.org/10.4040/jkan.2002.32.4.550
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Abstract
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PURPOSE: This study was conducted to determine whether low intensity regular exercise following dexamethasone treatment could attenuate steroid-induced muscle atrophy.
METHOD: 36 Wistar-rats(90-110g) were divided into six groups: control group(C), dexamethasone treatment group(D), sedentary group after normal sedentary period(C+S), sedentary group after dexamethasone treatment period(D+S), exercise group after normal sedentary period(C+E), and excercise group after dexamethasone treatment period(D+E). D, D+S, and D+E groups received dexamethasone injection(5mg/Kg) for seven days whereas C, C+S, and C+E groups received normal saline injection. Both C+E and D+E groups ran on a treadmill for 60 minutes/day(20minutes/4hours) at 15m/min and a 10degreegrade for seven recovery days.
RESULT: Post-weight(body weight before muscle dissection) of D group significantly decreased by 16.03%, and that of D+E group significantly increased by 15.51% compared with pre-weight(body weight before steroid treatment). Type II muscle(plantaris and gastrocnemius) weights of D group were significantly lower than those of C group. Myofibrillar protein contents of type II muscles
of D group tended to decrease comparing with C group. In D+E groups, body weights and relative weights of typeII muscles(muscle weight(mg)/post-weight(g)) tended to increase comparing with D+S group.
CONCLUSION: It is suggested that steroid- induced muscle atrophy can be ameliorated through low intensity regular exercise after dexamethasone treatment.
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Citations
Citations to this article as recorded by - Use of Animals for Nursing Research in Korea
Hae Young Yoo
Journal of Korean Biological Nursing Science.2015; 17(4): 324. CrossRef - Effect of DHEA Administration Alone or Exercise combined with DHEA before Steroid Treatment on Rat Hindlimb Muscles
Myoung-Ae Choe, Gyeong-Ju An
Journal of Korean Academy of Nursing.2009; 39(3): 321. CrossRef
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