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Effect of Ondansetron combined with Dexamethasone on Postoperative Nausea & Vomiting and Pain of Patients with Laparoscopic Hysterectomy
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Miok Nam, Haesang Yoon
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J Korean Acad Nurs 2009;39(1):44-52. Published online February 17, 2009
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DOI: https://doi.org/10.4040/jkan.2009.39.1.44
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 Abstract
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Purpose:
The purpose of this study was to compare the effects of ondansetron combined with dexamethasone on Post-Operative Nausea and Vomiting (PONV) and pain with ondansetron alone in patients with laparoscopy assisted vaginal hysterectomy under general anesthesia.
Methods:
Data were collected from April 1 through September 30, 2005 using a double blind method. Ondansetron 4 mg and dexamethasone 10 mg were administered to the experimental group (25 patients), and ondansetron 4 mg only to the control group (25 patients). The medications were administered through an intravenous line at the beginning peritoneum suture. PONV by Index of Nausea Vomiting and Retching (INVR), nausea by Visual Analogue Scale (VAS), and pain (VAS) were assessed at postoperative 1 hr, 3 hr, 6 hr, 24 hr, and 48 hr. Data were analyzed using repeated measures ANOVA, and Bonferroni methods.
Results:
The experimental group that received ondansetron combined with dexamethasone had less PONV (p=.048), and nausea (p=.012) than control group that received ondansetron alone. However, there was no difference in pain (p=.557) between the patients in the two groups.
Conclusion:
We conclude that the administration of ondansetron combined with dexamethasone is more effective than the administration of ondansetron alone to reduce PONV in patients with laparoscopic hysterectomy.
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Citations
Citations to this article as recorded by  - Analgesia for Gynecologic Oncologic Surgeries: A Narrative Review
Kaiwal Patel, Sukhman Shergill, Nalini Vadivelu, Kanishka Rajput
Current Pain and Headache Reports.2022; 26(1): 1. CrossRef - Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis
Stephanie Weibel, Gerta Rücker, Leopold HJ Eberhart, Nathan L Pace, Hannah M Hartl, Olivia L Jordan, Debora Mayer, Manuel Riemer, Maximilian S Schaefer, Diana Raj, Insa Backhaus, Antonia Helf, Tobias Schlesinger, Peter Kienbaum, Peter Kranke
Cochrane Database of Systematic Reviews.2020;[Epub] CrossRef - Pain management after laparoscopic hysterectomy: systematic review of literature and PROSPECT recommendations
Philipp Lirk, Juliette Thiry, Marie-Pierre Bonnet, Girish P Joshi, Francis Bonnet
Regional Anesthesia & Pain Medicine.2019; 44(4): 425. CrossRef - Comparing Effects of Two Different Types of Nei-Guan Acupuncture Stimulation Devices in Reducing Postoperative Nausea and Vomiting
Hanna Oh, Bo Hwan Kim
Journal of PeriAnesthesia Nursing.2017; 32(3): 177. CrossRef - Combination of 5-HT3 Antagonist and Dexamethasone Is Superior to 5-HT3 Antagonist Alone for PONV Prophylaxis After Laparoscopic Surgeries
Anirban Som, Sulagna Bhattacharjee, Souvik Maitra, Mahesh K Arora, Dalim Kumar Baidya
Anesthesia & Analgesia.2016; 123(6): 1418. CrossRef - Effect of Evidence-based Clinical Practice Guidelines for Promotion of Postoperative Nausea and Vomiting of Patients with Laparoscopic Hysterectomy
Sung-Hee Lee, Sung-Jung Hong, Hwa Sun Kim, Younghoon Jeon
Korean Journal of Adult Nursing.2015; 27(5): 481. CrossRef - Cost Analysis of Post Operative Pain Management for Surgical Patients using PCA
Sung-Jung Hong, Eunjoo Lee
Journal of Korean Academy of Fundamentals of Nursing.2013; 20(2): 137. CrossRef - Impact of perioperative dexamethasone on postoperative analgesia and side-effects: systematic review and meta-analysis
N.H. Waldron, C.A. Jones, T.J. Gan, T.K. Allen, A.S. Habib
British Journal of Anaesthesia.2013; 110(2): 191. CrossRef
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