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Effects of Psychosocial Interventions on Cortisol and Immune Parameters in Patients with Cancer: A Meta-analysis
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Pok Ja Oh, Eun-su Jang
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J Korean Acad Nurs 2014;44(4):446-457. Published online August 29, 2014
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DOI: https://doi.org/10.4040/jkan.2014.44.4.446
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 Abstract
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Purpose
This study was done to evaluate the effects of psychosocial interventions on cortisol and immune response in adult patients with cancer.
Methods
MEDLINE via PubMed, Cochrane Library CENTRAL, EMBASE, CINAHL and domestic electronic databases were searched. Twenty controlled trials (11 randomized and 9 non-randomized trials) met the inclusion criteria with a total of 862 participants. Methodological quality was assessed using the Cochrane's Risk of Bias for randomized studies and the Risk of Bias Assessment tool for non randomized studies. Data were analyzed using the RevMan 5.2.11 program of Cochrane library.
Results
Overall, study quality was moderate to high. The weighted average effect size across studies was -0.32 (95% CI [-0.56, -0.07], p=.010, I2=45%) for cortisol concentration, -0.62 (95%CI [-0.96,-0.29], p<.001, I2=0%) for T lymphocyte (CD3) and -0.45 (95%CI [-0.74, -0.16], p=.003, I2=0%) for Th lymphocyte (CD4) numbers. Psychosocial interventions were not effective for Tc lymphocyte (CD4), NK cell, monocyte, and cytokine response.
Conclusion
Although these results provide only small evidence of successful immune modulation, they support the conclusion that psychosocial interventions can assist cancer patients in reducing emotional distress and improving immune response.
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Citations
Citations to this article as recorded by  - Depression and Cancer (literature review)
A. N. Blinkov
V.M. BEKHTEREV REVIEW OF PSYCHIATRY AND MEDICAL PSYCHOLOGY.2020; (2): 16. CrossRef - Meta-analysis of psychosocial interventions on survival time in patients with cancer
P.J. Oh, S.R. Shin, H.S. Ahn, H.J. Kim
Psychology & Health.2016; 31(4): 396. CrossRef - Cognitive Behavioral Therapy for Primary Insomnia: A Meta-analysis
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Journal of the Korea Academia-Industrial cooperation Society.2016; 17(9): 407. CrossRef - Chemotherapy-related Cognitive Impairment and Quality of Life in People with Colon Cancer: The Mediating Effect of Psychological Distress
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Journal of Korean Academy of Nursing.2016; 46(1): 19. CrossRef - Effects of Non-pharmacological Interventions on Primary Insomnia in Adults Aged 55 and Above: A Meta-analysis
Ji Hyun Kim, Pok Ja Oh
Korean Journal of Adult Nursing.2016; 28(1): 13. CrossRef - The Effect of a Community-Based Self-Management Program for Patients at Thyroid Cancer-Diagnosis Stage : a Pilot Study
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Journal of Korean Public Health Nursing.2015; 29(3): 582. CrossRef - Effects of Dignity Interventions on Psychosocial and Existential Distress in Terminally ill Patients: A Meta-analysis
Pok Ja Oh, Sung-Rae Shin
Journal of Korean Academy of Nursing.2014; 44(5): 471. CrossRef
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